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Titolo:
ET-1-INDUCED BRONCHOCONSTRICTION IS MEDIATED VIA ETB RECEPTOR IN MICE
Autore:
NAGASE T; AOKI T; OKA T; FUKUCHI Y; OUCHI Y;
Indirizzi:
UNIV TOKYO,FAC MED,DEPT GERIATR,BUNKYO KU,7-3-1 HONGO TOKYO 113 JAPAN UNIV TOKYO,FAC MED,DEPT PATHOL TOKYO 113 JAPAN IMPERIAL HOUSEHOLD AGCY TOKYO 100 JAPAN
Titolo Testata:
Journal of applied physiology
fascicolo: 1, volume: 83, anno: 1997,
pagine: 46 - 51
SICI:
8750-7587(1997)83:1<46:EBIMVE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY SYSTEM RESISTANCE; ENDOTHELIN RECEPTOR; VASOCONSTRICTOR PEPTIDE; INDUCED CONSTRICTION; PULMONARY TISSUES; SUBTYPES; POTENT; LUNG; EXPRESSION; DEFICIENT;
Keywords:
BQ-123; BQ-788; AIRWAY RESISTANCE; WILD-TYPE MICE; ENDOTHELIN-1; ENDOTHELIN(A) RECEPTORS; ENDOTHELIN(B) RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
T. Nagase et al., "ET-1-INDUCED BRONCHOCONSTRICTION IS MEDIATED VIA ETB RECEPTOR IN MICE", Journal of applied physiology, 83(1), 1997, pp. 46-51

Abstract

Endothelin (ET)-1 is one of the most potent agonists of airway smoothmuscle and can act via two different ET receptor subtypes, i.e., ETA and ETB. To determine the effects of ET-1 on in vivo pulmonary function and which ET receptors are involved in murine lungs, we investigated1) the effects of ET and sarafotoxin S6c (S6c), a selective ETB agonist, on pulmonary function and 2) the effects of BQ-123 and BQ-788, specific ETA- and ETB-receptor antagonists, on ET-1-induced bronchoconstriction. ICR mice were anesthetized and mechanically ventilated (frequency = 2.5 Hz, tidal volume = 8 ml/kg, positive end-expiratory pressure= 3 cmH(2)O). Intravenous ET-1, ET-2, and ET-3 increased lung resistance similarly and equipotently, whereas S6c elicited a greater degree of bronchoconstriction. Mice were then pretreated with saline (Sal), BQ-123 (0.2, 1, and 5 mg/kg), or BQ-788 (0.2, 1, and 5 mg/kg) before administration of ET-1 (10(-7) mol/kg iv). No dose of BQ-123 blocked ET-1-induced constriction, whereas pretreatment with each dose of BQ-788 significantly inhibited ET-1-induced responses. There were significantdifferences in morphometrically assessed airway constriction between Sal and BQ-788 and between BQ-123 and BQ-788, whereas no significant difference was observed between Sal and BQ-123. There were no significant morphometric differences in the airway wall area among the three groups. These observations suggest that the ETB- but not ETA-receptor subtype may mediate the changes in murine pulmonary function in responseto ET-1. In addition, the ETB-receptor antagonist reduces ET-1-induced airway narrowing by affecting airway smooth muscle contraction in mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 12:59:33