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Titolo:
Comparative behavioural toxicity of domoic acid and kainic acid in neonatal rats
Autore:
Doucette, TA; Strain, SM; Allen, GV; Ryan, CL; Tasker, RAR;
Indirizzi:
Univ Prince Edward Isl, Atlantic Vet Coll, Dept Anat & Physiol, Charlottetown, PE C1A 4P3, Canada Univ Prince Edward Isl Charlottetown PE Canada C1A4P3 PE C1A 4P3, Canada Dalhousie Univ, Dept Anat & Neurobiol, Halifax, NS, Canada Dalhousie UnivHalifax NS Canada t Anat & Neurobiol, Halifax, NS, Canada Univ Prince Edward Isl, Dept Psychol, Charlottetown, PE C1A 4P3, Canada Univ Prince Edward Isl Charlottetown PE Canada C1A 4P3 PE C1A 4P3, Canada
Titolo Testata:
NEUROTOXICOLOGY AND TERATOLOGY
fascicolo: 6, volume: 22, anno: 2000,
pagine: 863 - 869
SICI:
0892-0362(200011/12)22:6<863:CBTODA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; MONKEYS MACACA-FASCICULARIS; NMDA RECEPTOR ANTAGONIST; CENTRAL-NERVOUS-SYSTEM; INDUCED SEIZURES; SHELLFISH TOXIN; IMMATURE BRAIN; NEUROTOXICITY; GLUTAMATE; MUSSELS;
Keywords:
domoic acid; kainic acid; excitatory amino acid; glutamate; development; behaviour;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Tasker, RAR Univ Prince Edward Isl, Atlantic Vet Coll, Dept Anat & Physiol, 550 Univ Ave, Charlottetown, PE C1A 4P3, Canada Univ Prince Edward Isl 550 Univ Ave Charlottetown PE Canada C1A 4P3
Citazione:
T.A. Doucette et al., "Comparative behavioural toxicity of domoic acid and kainic acid in neonatal rats", NEUROTOX T, 22(6), 2000, pp. 863-869

Abstract

Cumulative behavioural toxicity was measured in groups of male and female rat pups (n = 6/sex) at different stages of postnatal development. Dose-response curves (DRCs) for toxicity produced by domoic acid (DOM) were generated using animals on postnatal days (PND) 0, 5, 14, and 22, using a behavioural rating scale. In a subsequent experiment, DRCs for toxicity generated by either DOM or kainic acid were produced in rats at PND 8 and 14 fur comparison between the two toxins. DOM was found to be a very potent neurotoxin in newborn rats and the potency of DOM progressively decreased with increasing age (interpolated ED50 = 0.12, 0.15, 0.30, and 1.06 mg/kg at PND 0, 5, 14, and 22, respectively). In addition, the patterns of behavioural expression were found to differ with age. Comparisons between DOM and kainic acid revealed that DOM was approximately six-fold more potent than kainate at both PND 8 and PND 14 and that both toxins were approximately two-fold less potent in PND 14 rats, compared to PND 8. This implies that the mechanism(s)responsible for reduced potency is/are similar between the two compounds. Consistent with previous reports, however, there were both similarities anddifferences in the observed patterns of behavioural toxicity produced by the two toxins at both ages. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:34:17