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Titolo:
Differential sensitivities to the lethal, but not the neurotoxic, effects of p-chloroamphetamine in inbred rat strains
Autore:
Fernandez, F; Aguerre, S; Mormede, P; Chaouloff, F;
Indirizzi:
Inst F Magendie, INRA, INSERM, U471, F-33077 Bordeaux, France Inst F Magendie Bordeaux France F-33077 , U471, F-33077 Bordeaux, France
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 297, anno: 2001,
pagine: 53 - 57
SICI:
0304-3940(20010105)297:1<53:DSTTLB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; SEROTONIN; BRAIN; 5-HT; FENFLURAMINE; RELEASE; PHARMACOLOGY; MECHANISM; BEHAVIOR; ECSTASY;
Keywords:
p-chloroamphetamine; frontocortical serotonergic neurons; strains; synaptosomal [H-3]5-hydroxytryptamine reuptake; [H-3]citalopram binding; activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Chaouloff, F Inst F Magendie, INRA, INSERM, U471, Rue Camille St-Saens, F-33077 Bordeaux, France Inst F Magendie Rue Camille St-Saens Bordeaux France F-33077
Citazione:
F. Fernandez et al., "Differential sensitivities to the lethal, but not the neurotoxic, effects of p-chloroamphetamine in inbred rat strains", NEUROSCI L, 297(1), 2001, pp. 53-57

Abstract

The Lewis, Fischer 344, Brown Norway, Spontaneously Hypertensive, and Wistar-Kyoto inbred rat strains were, respectively, compared for the lethal andneurotoxic effects of acute p-chloroamphetamine (PCA, 2.5-10 mg/kg i.p.). The lethal properties of the amphetamine were recorded within 24 h after its administration whereas neurotoxicity (as assessed by frontocortical 5-hydroxytryptamine (5-HT) reuptake and 5-HT transporter binding assays) was analyzed 1 week after PCA administration. Preliminary experiments indicated that neither the rapid hyperlocomotor and/or the hypoexploratory effect of PCA nor the in vitro potency of PCA to inhibit frontocortical [H-3]5-HT reuptake varied between strains. On the other hand, strain differences were observed with respect to the rapid fatal effects of the 5 and 10 mg/kg doses ofPCA administration. Lastly, frontocortical [H-3]5-HT reuptake and [H-3]citalopram binding at 5-HT transporters diminished in a dose-dependent, but strain-independent, manner 1 week after the acute injection of PCA. This study reveals an independency between the mechanisms underlying the fatal effects of PCA on the one hand, and the longterm damaging effects of PCA on serotonergic neurons on the other hand. (C) 2001 Elsevier Science Ireland Ltd. All rig hts reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:20:49