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Titolo:
Regulation of rat hippocampal neural cadherin in the kainic acid induced seizures
Autore:
Fujita, M; Aihara, N; Yamamoto, M; Ueki, T; Asai, K; Tada, T; Kato, T; Yamada, K;
Indirizzi:
Nagoya City Univ, Sch Med, Dept Neurosurg, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Med, Strateg Promot Syst Brain Sci, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Med, Dept Bioregulat, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Nursing, Dept Pathol, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 297, anno: 2001,
pagine: 13 - 16
SICI:
0304-3940(20010105)297:1<13:RORHNC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPRESSION; ADHESION;
Keywords:
N-cadherin; kainic acid; seizures; hippocampus; cell death; in situ hybridization; immunohistochemistry; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Fujita, M Nagoya City Univ, Sch Med, Dept Neurosurg, Mizuho Ku, 1 Kawasumi, Nagoya, Aichi 4678601, Japan Nagoya City Univ 1 Kawasumi Nagoya Aichi Japan 4678601 01, Japan
Citazione:
M. Fujita et al., "Regulation of rat hippocampal neural cadherin in the kainic acid induced seizures", NEUROSCI L, 297(1), 2001, pp. 13-16

Abstract

Regulation of neural (N-) cadherin expression in the hippocampus was era mined by in situ hybridization a nd immunohistochemistry methods in the rat model of kainic acid (KA) induced seizures. After 12 and 24 h of KA administration, mRNA expression level of N-cadherin decreased in the hippocampal CA1 and CA3 area in parallel with decrease of the number of neural cells. Incontrast, after 48 h and 7 days, mRNA expression level recovered partially, although the number of neural cells remained small. In addition, immunohistochemical staining indicated that N-cadherin protein expression of survived neurons increased significantly after 48 h of KA administration. These results indicated that N-cadherin might be involved in neuronal reconstruction at the hippocampus. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:22:04