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Titolo:
Direct pathways to the supraoptic nucleus from the brainstem and the main olfactory bulb are activated at parturition in the rat
Autore:
Meddle, SL; Leng, G; Selvarajah, JR; Bicknell, RJ; Russell, JA;
Indirizzi:
Univ Edinburgh, Sch Med, Dept Biomed Sci, Edinburgh EH8 9XD, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9XD Midlothian, Scotland Babraham Inst, Neuroendocrinol Lab, Cambridge CB2 4AT, England Babraham Inst Cambridge England CB2 4AT Lab, Cambridge CB2 4AT, England
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 101, anno: 2000,
pagine: 1013 - 1021
SICI:
0306-4522(2000)101:4<1013:DPTTSN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREOPTIC AREA; VASOPRESSIN-CONTAINING NEURONS; RECEPTOR MESSENGER-RNA; PARAVENTRICULAR NUCLEUS; MATERNAL-BEHAVIOR; C-FOS; CATECHOLAMINERGIC NEURONS; LAMINA TERMINALIS; STRIA TERMINALIS; LACTATING RATS;
Keywords:
catecholamines; Fos; nucleus tractus solitarii; organum vasculosum of the lamina terminalis; retrograde tracing; ventrolateral medulla;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Meddle, SL Univ Edinburgh, Sch Med, Dept Biomed Sci, George Sq, Edinburgh EH8 9XD, Midlothian, Scotland Univ Edinburgh George Sq Edinburgh MidlothianScotland EH8 9XD
Citazione:
S.L. Meddle et al., "Direct pathways to the supraoptic nucleus from the brainstem and the main olfactory bulb are activated at parturition in the rat", NEUROSCIENC, 101(4), 2000, pp. 1013-1021

Abstract

Sensory input from female reproductive structures is paramount for the co-ordination of neuroendocrine changes at parturition. Using a retrograde tracer (fluorescent latex microspheres) in combination with Fos (as an indicator of neuronal activation) and tyrosine hydroxylase (to identify catecholaminergic neurons) immunocytochemistry we identified cells within the brainstem and main olfactory bulb that project to the supraoptic nucleus, and which become significantly activated at parturition (compared to virgin rats and rats on the day of expected parturition). Within the A2/C2 region in the nucleus tractus solitarii, 60% of the projecting activated cells were catecholaminergic, as were 59% of such cells in the A1/C1 region of the ventrolateral medulla. This suggests that oxytocin and vasopressin neurons within the supraoptic nucleus are stimulated at parturition via afferent inputs from the brainstem, but the input is not exclusively noradrenergic. Within themitral layer of the main olfactory bulb, cells that projected to the supraoptic nucleus were significantly activated, suggesting that the olfactory system may regulate supraoptic nucleus cell firing at parturition. The preoptic area, organum vasculosum of the lamina terminalis and medial amygdala contained cells that projected to the supraoptic nucleus but these projections were not significantly activated at parturition, although non-projectingcells in these regions were. On the expected day of parturition, but before birth, projections from the organum vasculosum of the lamina terminalis to the supraoptic nucleus became significantly activated. These findings provide evidence of direct afferent pathways to the supraoptic nucleus from the brain stem and olfactory bulbs that are activated at parturition. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 06/04/20 alle ore 01:05:22