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Titolo:
Long-term induction of Fos-related antigen-2 after methamphetamine-, methylenedioxymethamphetamine-, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and trimethyltin-induced brain injury
Autore:
Pennypacker, KR; Yang, X; Gordon, MN; Benkovic, S; Miller, D; OCallaghan, JP;
Indirizzi:
Univ S Florida, Coll Med, Dept Pharmacol & Therapeut, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 rmacol & Therapeut, Tampa, FL 33612 USA NIOSH, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA NIOSH Morgantown WV USA 26505 Control & Prevent, Morgantown, WV 26505 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 101, anno: 2000,
pagine: 913 - 919
SICI:
0306-4522(2000)101:4<913:LIOFAA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
AP-1 TRANSCRIPTION FACTORS; CENTRAL NERVOUS-SYSTEM; RAT HIPPOCAMPUS; SUBSTITUTED AMPHETAMINES; PROLONGED EXPRESSION; NEURONAL DEATH; C57BL/6J MOUSE; DNA-BINDING; NEUROTOXICITY; PROTEINS;
Keywords:
transcription factor; gene regulation; neuronal regeneration; AP-1; glial fibrillary acidic protein; terminal degeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Pennypacker, KR Univ S Florida, Coll Med, Dept Pharmacol & Therapeut, 12901 Bruce B Downs Blvd, Tampa, FL 33612 USA Univ S Florida 12901 Bruce B Downs Blvd Tampa FL USA 33612
Citazione:
K.R. Pennypacker et al., "Long-term induction of Fos-related antigen-2 after methamphetamine-, methylenedioxymethamphetamine-, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and trimethyltin-induced brain injury", NEUROSCIENC, 101(4), 2000, pp. 913-919

Abstract

A long-term induction of Fos-related antigens has been shown in neurons after brain injury, suggesting that Fos-related antigens are involved in enhancing the transcription of genes related to the process of regeneration andrepair. In the present study, we report that levels of Fos-related antigen-2 are elevated in several models of chemically induced brain injury. Trimethyltin, which causes degeneration of neurons primarily in the hippocampus and other limbic regions, results in a five-fold induction of Fos-related antigen-2 immunoreactivity in neurons in the pyramidal and dentate layers ofthe hippocampus starting at seven days post-treatment and persisting for 60 days. Methamphetamine and methylenedioxymethamphetamine, agents which cause degeneration of dopaminergic nerve terminals in the striatum of the mouse, cause an increase in Fos-related antigen-2 immunoreactivity which beginsat three days post-treatment and returns to basal levels by days 5 and 15,respectively. Treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine elevated levels of Fos-related antigen-2 in the mouse striatum at three days post-treatment. This abbreviated time-course of Fos-related antigen-2 induction is consistent with less severe insult (terminal damage) relative to trimethyltin (cell death), but induction occurs during the period of regeneration and repair in both models. Dexfenfluramine, a non-neurotoxic amphetamine, does not induce Fos-related antigen-2 expression. Decreasing core temperature of the mouse, which blocks amphetamine-induced neurotoxicity, alsoblocks Fos-related antigen-2 induction. In summary, Fos-related antigen-2 is induced in models of both cell death and terminal degeneration, suggesting that this transcription factor may serve as a universal signal transduction molecule involved in the regulation of genes related to regeneration and repair in the CNS. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 08:55:32