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Titolo:
Neurotensin gene expression and behavioral responses following administration of psychostimulants and antipsychotic drugs in dopamine D-3 receptor deficient mice
Autore:
Betancur, C; Lepee-Lorgeoux, I; Cazillis, M; Accili, D; Fuchs, S; Rostene, W;
Indirizzi:
Hop St Antoine, INSERM, U339, F-75571 Paris, France Hop St Antoine ParisFrance F-75571 INSERM, U339, F-75571 Paris, France Hop St Antoine, INSERM, U142 515, F-75571 Paris, France Hop St Antoine Paris France F-75571 ERM, U142 515, F-75571 Paris, France NIDDKD, Diabet Branch, Bethesda, MD 20892 USA NIDDKD Bethesda MD USA 20892 IDDKD, Diabet Branch, Bethesda, MD 20892 USA Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 unol, IL-76100 Rehovot, Israel
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 24, anno: 2001,
pagine: 170 - 182
SICI:
0893-133X(200102)24:2<170:NGEABR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOS MESSENGER-RNA; HUMAN COCAINE FATALITIES; VENTRAL TEGMENTAL AREA; NUCLEUS-ACCUMBENS; RAT NEOSTRIATUM; ACUTE METHAMPHETAMINE; LOCOMOTOR-ACTIVITY; BASAL GANGLIA; UP-REGULATION; NEUROMEDIN-N;
Keywords:
dopamine D-3 receptor; neurotensin; cocaine; amphetamine; haloperidol; in situ hybridization; behavioral sensitization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Betancur, C Fac Med, INSERM, U513, 8 Rue Gen Sarrail, F-94010 Creteil, France Fac Med 8 Rue Gen Sarrail Creteil France F-94010 teil, France
Citazione:
C. Betancur et al., "Neurotensin gene expression and behavioral responses following administration of psychostimulants and antipsychotic drugs in dopamine D-3 receptor deficient mice", NEUROPSYCH, 24(2), 2001, pp. 170-182

Abstract

Exposure to psychostimulants and antipsychotics increases neurotensin (NT)gene expression in the striatum and nucleus accumbens. To investigate the contribution of D-3 receptors to these effects toe used mice with targeted disruption of the D-3 receptor gene. Basal NT mRNA expression was similar inD-3 receptor mutant mice and wild-type animals. Acute administration of haloperidol increased NT gene expression in the striatum in D-3 +/+, D-3 +/- and D-3 -/- mice. Similarly, acute cocaine and amphetamine induced NT mRNA expression in the nucleus accumbens shell and olfactory tubercle to a comparable extent in D-3 mutants and wild-type mice. Daily injection of cocaine for seven days increased NT mRNA in it restricted population of neurons in the dorsomedial caudal striatum of D-3 +/+ mice, but not in D-3 -/- and D-3+/- animals. No differences were observed between D-3 receptor mutant miceand wild-type littermates in the locomotor activity and stereotyped behaviors induced by repeated cocaine administration. These findings demonstrate that dopamine D-3 receptors are not necessary for the acute NT mRNA response to drugs of abuse and antipsychotics but appear to play a role in the regulation of NT gene induction in striatal neurons after repented cocaine. Inaddition, ota results indicate that the acute locomotor response to cocaine and development of psychostimulant-induced behavioral sensitization do not require functional D-3 receptors. [Neuropsychopharmacology 24:170-182, 2001] (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 01:07:34