Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Endogenous 5-HT tonically inhibits spontaneous firing activity of dorsal hippocampus CA1 pyramidal neurons through stimulation of 5-HT1A receptors inquiet awake rats: In vivo electrophysiological evidence
Autore:
Kasamo, K; Suzuki, T; Tada, K; Ueda, N; Matsuda, E; Ishikawa, K; Kojima, T;
Indirizzi:
Nihon Univ, Sch Med, Dept Neuropsychiat, Tokyo 1738610, Japan Nihon Univ Tokyo Japan 1738610 Dept Neuropsychiat, Tokyo 1738610, Japan Nihon Univ, Sch Med, Dept Pharmacol, Tokyo 1738610, Japan Nihon Univ Tokyo Japan 1738610 Med, Dept Pharmacol, Tokyo 1738610, Japan
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 24, anno: 2001,
pagine: 141 - 151
SICI:
0893-133X(200102)24:2<141:E5TISF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHYTHMICAL SLOW ACTIVITY; ANTAGONIST WAY-100635; SEROTONIN RECEPTOR; RAPHE NUCLEUS; SINGLE-CELL; SLEEP; RITANSERIN; PINDOLOL; WAKING; BRAIN;
Keywords:
endogenous serotonin (5-HT); awake; unrestrained; CA1 pyramidal neuron; firing activity; tonic inhibition; 5-HT1A receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Kasamo, K Nihon Univ, Sch Med, Dept Neuropsychiat, Oyaguchi Kamimachi 30-1, Tokyo 1738610, Japan Nihon Univ Oyaguchi Kamimachi 30-1 Tokyo Japan 1738610 0, Japan
Citazione:
K. Kasamo et al., "Endogenous 5-HT tonically inhibits spontaneous firing activity of dorsal hippocampus CA1 pyramidal neurons through stimulation of 5-HT1A receptors inquiet awake rats: In vivo electrophysiological evidence", NEUROPSYCH, 24(2), 2001, pp. 141-151

Abstract

The present study was performed to examine an overall effect of endogenousserotonin (5-HT) on the spontaneous firing activity of the dorsal hippocampus CA1 pyramidal neurons in quiet awake rats. A selective 5-HT,A antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2(-pyridinyl)cyclohexanecarboxamide (WAY-100635: 0.03-0.2 mg/kg, s.c.) significantly increased the firing activity. A depletion of 5-HT with parachlorophenylalanine (PCPA: 500 mg/kg/day X 3 days) completely abolished this increasing effect of WAY-100635. The baseline spike frequency of the PCPA-treated rats (3.90 +/- 0.39 Hz) was significantly higher than that of the vehicle-treated mts (2.09 +/-0.29 Hz). A 5-HT2A antagonist ritanserin (1 mg/kg, i.p.) and a 5-HT3/4 antagonist 2-methoxy-4-amino-5-chloro benzoic acid 2-(diethylamino) ethyl ester (SDZ-205557: 3 mg/kg,s.c.) did not modify the firing activity and the increasing effect of WAY-100635. These results suggest that, in quiet awake rats, endogenous 5-HT would tonically inhibit the spontaneous firing activityof the CA1 pyramidal neurons mainly through stimulating 5-HT1A receptors. [Neuropsychopharmacology 24:141-151, 2001] (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:19:41