Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Drug addiction, dysregulation of reward, and allostasis
Autore:
Koob, GF; Le Moal, M;
Indirizzi:
Scripps Clin & Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 col, La Jolla, CA 92037 USA Univ Bordeaux 2, INSERM, U259, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 , U259, F-33076 Bordeaux, France
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 24, anno: 2001,
pagine: 97 - 129
SICI:
0893-133X(200102)24:2<97:DADORA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; NICOTINE ABSTINENCE SYNDROME; MESOLIMBIC DOPAMINE SYSTEM; COCAINE-SEEKING BEHAVIOR; CENTRAL-NERVOUS-SYSTEM; GLUCOCORTICOID RECEPTOR ACTIVATION; PIMOZIDE BLOCKS ESTABLISHMENT; CONDITIONED PLACE PREFERENCE; MEDIAL PREFRONTAL CORTEX; VENTRAL TEGMENTAL AREA;
Keywords:
allostasis; drug addiction; reward dysregulation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
303
Recensione:
Indirizzi per estratti:
Indirizzo: Koob, GF Scripps Clin & Res Inst, Dept Neuropharmacol, CVN-7,10550 N Torrey Pines Rd, La Jolla, CA 92037 USA Scripps Clin & Res Inst CVN-7,10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
G.F. Koob e M. Le Moal, "Drug addiction, dysregulation of reward, and allostasis", NEUROPSYCH, 24(2), 2001, pp. 97-129

Abstract

This paper reviews recent developments in the neurocircuitry and neurobiology of addiction from a perspective of allostasis. A model is proposed for brain changes that occur during the development of addiction that explain the persistent vulnerability to relapse long after drug-taking has ceased. Addiction is presented as a cycle of spiralling dysregulation of brain reward systems that progressively increases, resulting in the compulsive use andloss of control over drug-taking. The development of addiction recruits different sources of reinforcement, different neuroadaptive mechanisms, and different neurochemical changes to dysregulate the brain reward system. Counteradaptive processes such as opponent-process that are part of normal homeostatic limitation of reward function fail to return within the normal homeostatic range and are hypothesized to form an allostatic state. Allostasis from the addiction perspective is defined as the process of maintaining apparent reward function stability by changes in brain reward mechanisms. The allostatic state represents a chronic deviation of reward set point and is fueled not only by dysregulation of reward circuits per se, but also by theactivation of brain and hormonal stress responses. The manifestation of this allostatic state as compulsive drug-taking and loss of control over drug-taking is hypothesized to be expressed through activation of brain circuits involved in compulsive behavior such as the cortico-striatal-thalamic loop. The view that addiction is the pathology that results from an allostaticmechanism using the circuits established for natural rewards provides a realistic approach to identifying the neurobiological factors that produce vulnerability to addiction and relapse. [Neuropsychopharmacology 24:97-129, 2002] (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:01:22