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Titolo:
Spinal cord atrophy and reorganization of motoneuron connections followinglong-standing limb loss in primates
Autore:
Wu, CWH; Kaas, JH;
Indirizzi:
Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA Vanderbilt Univ Nashville TN USA 37240 t Psychol, Nashville, TN 37240 USA NINDS, Human Cortic Physiol Sect, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 tic Physiol Sect, NIH, Bethesda, MD 20892 USA
Titolo Testata:
NEURON
fascicolo: 3, volume: 28, anno: 2000,
pagine: 967 - 978
SICI:
0896-6273(200012)28:3<967:SCAARO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY MOTOR CORTEX; NEURON-SPECIFIC EPITOPE; ISCHEMIC NERVE BLOCK; SELECTIVE REINNERVATION; MEDIAL GASTROCNEMIUS; GAMMA-MOTONEURONS; NEUROMUSCULAR-JUNCTION; HORSERADISH-PEROXIDASE; INTERCOSTAL MUSCLES; PARTIAL DENERVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Kaas, JH Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA VanderbiltUniv Nashville TN USA 37240 , Nashville, TN 37240 USA
Citazione:
C.W.H. Wu e J.H. Kaas, "Spinal cord atrophy and reorganization of motoneuron connections followinglong-standing limb loss in primates", NEURON, 28(3), 2000, pp. 967-978

Abstract

Primates with long-standing therapeutic amputations of a limb at a young age were used to investigate the possibility that deefferented motor nerves sprout to new muscle targets. Injections of anatomical tracers into the muscles proximal to the amputated stump labeled a larger extent of motoneuronsthan matched injections on the intact side or in normal animals, includingmotoneurons that would normally supply only the missing limb muscles. Although the total numbers of distal limb motoneurons remained normal, some distal limb motoneurons on the amputated side were smaller in size and simplerin form. These results suggest that deprived motoneurons survive and retain function by reinnervating new muscle targets. The sprouted motor efferents may account for some of the reorganization of primary motor cortex that follows long-standing amputation.

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Documento generato il 28/09/20 alle ore 17:34:13