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Titolo:
PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses
Autore:
Daw, MI; Chittajallu, R; Bortolotto, ZA; Dev, KK; Duprat, F; Henley, JM; Collingridge, GL; Isaac, JTR;
Indirizzi:
Univ Bristol, MRC, Ctr Synapt Plast, Dept Anat, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD Bristol BS8 1TD, Avon, England
Titolo Testata:
NEURON
fascicolo: 3, volume: 28, anno: 2000,
pagine: 873 - 886
SICI:
0896-6273(200012)28:3<873:PPIWCG>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOMAIN-CONTAINING PROTEIN; KINASE M-ZETA; PYRAMIDAL CELLS; BINDING-PROTEIN; AREA CA1; SYNAPTIC TRANSMISSION; SELECTIVE INHIBITORS; GLUTAMATE RECEPTORS; CA2+ PERMEABILITY; SILENT SYNAPSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Isaac, JTR Univ Bristol, MRC, Ctr Synapt Plast, Dept Anat, Univ Walk, Bristol BS8 1TD, Avon, England Univ Bristol Univ Walk Bristol Avon England BS8 1TD on, England
Citazione:
M.I. Daw et al., "PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses", NEURON, 28(3), 2000, pp. 873-886

Abstract

We investigated the role of PDZ proteins (GRIP, ABP, and PICK1) interacting with the C-terminal GluR2 by infusing a ct-GluR2 peptide ("pep2-SVKI") into CA1 pyramidal neurons in hippocampal slices using whole-cell recordings. Pep2-SVKI, but not a control or PICK1 selective peptide, caused AMPAR-mediated EPSC amplitude to increase in approximately one-third of control neurons and in most neurons following the prior induction of LTD. Pep2-SVKI alsoblocked LTD; however, this occurred in all neurons. A PKC inhibitor prevented these effects of pep2-SVKI on synaptic transmission and LTD. We proposea model in which the maintenance of LTD involves the binding of AMPARs to PDZ proteins to prevent their reinsertion. We also present evidence that PKC regulates AMPAR reinsertion during dedepression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 13:01:21