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Titolo:
N-acetylaspartate and creatine levels measured by H-1 MRS relate to recognition memory
Autore:
Ferrier, CH; Alarcon, G; Glover, A; Koutroumanidis, M; Morris, RG; Simmons, A; Elwes, RDC; Cox, T; Binnie, CD; Polkey, CE;
Indirizzi:
Univ London Kings Coll Hosp, Dept Clin Neurophysiol, Inst Epileptol, London SE5 9RS, England Univ London Kings Coll Hosp London England SE5 9RS ndon SE5 9RS, England Inst Psychiat, London, England Inst Psychiat London EnglandInst Psychiat, London, England Univ Amsterdam, Acad Med Ctr, Fac Geneeskunde, NL-1012 WX Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1012 WX X Amsterdam, Netherlands Univ Complutense, Fac Med, Dept Fisiol, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 Dept Fisiol, E-28040 Madrid, Spain
Titolo Testata:
NEUROLOGY
fascicolo: 12, volume: 55, anno: 2000,
pagine: 1874 - 1883
SICI:
0028-3878(200012)55:12<1874:NACLMB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; MAGNETIC-RESONANCE SPECTROSCOPY; RABBIT FOLLOWING STIMULATION; LONG-LASTING POTENTIATION; SYNAPTIC TRANSMISSION; PERFORANT PATH; DENTATE AREA; LOBECTOMY; IMPAIRMENT; PERFORMANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Alarcon, G Univ London Kings Coll Hosp, Dept Clin Neurophysiol, Inst Epileptol, Denmark Hill, London SE5 9RS, England Univ London Kings Coll Hosp Denmark Hill London England SE5 9RS
Citazione:
C.H. Ferrier et al., "N-acetylaspartate and creatine levels measured by H-1 MRS relate to recognition memory", NEUROLOGY, 55(12), 2000, pp. 1874-1883

Abstract

Objectives: To investigate the relationship between recognition memory andmetabolite levels in medial structures of the temporal lobes in the livinghuman brain. Methods: Proton MRS (H-1 MRS) and the intracarotid amobarbital test were performed in 16 epileptic patients found suitable for temporal lobectomy. All patients had mesial temporal sclerosis. Metabolite ratios between N-acetylaspartate (NAA), creatine and phosphocreatine (Cr + PCr), andcholine-containing compounds (Cho) [NAA/(Cr + PCr), NAA/Cho, and NAA/(Cr PCr + Cho)] were calculated for H-1 MRS voxels that included the amygdala,anterior half of the hippocampus, and underlying subiculum. Metabolite ratios were correlated with unilateral memory scores estimated by the intracarotid amobarbital test for words, objects, faces, and total score. Results: The total memory score, memory for objects and faces, and NAA/(Cr + PCr) were significantly lower for the hemisphere ipsilateral to the resection. Theasymmetry indexes for NAA/(Cr + PCr) correlated with asymmetry indexes forwords (rho = 0.82, p = 0.0001) and total memory (rho = 0.72, p = 0.002). Analysis of memory scores and metabolite ratios from all 32 hemispheres revealed a correlation between NAA/(Cr + PCr) and memory for words (rho = 0.45,p = 0.009). A correlation between memory for words and NAA/(Cr + PCr) existed in the contralateral (rho = 0.58, p = 0.019) and in the right (rho = 0.51, p = 0.045) hemispheres, and a trend was found in the left hemispheres (rho = 0.48, p = 0.06). Conclusion: There is a correlation between memory for words and the NAA/(Cr + PCr) ratio from medial temporal structures in patients with mesial temporal sclerosis. The findings suggest that medial temporal structures and adjacent neocortex play a significant role in recognition memory in humans, particularly for words.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:54:44