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Titolo:
Expression and hypoxic regulation of angiopoietins in human astrocytomas
Autore:
Ding, H; Roncari, L; Wu, XL; Lau, N; Shannon, P; Nagy, A; Guha, A;
Indirizzi:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Inst, Toronto, ON M5G 1X5, Canada Toronto Hosp, Dept Pathol & Lab Med, Div Neuropathol, Div Neurosurg, Toronto, ON M5T 2S8, Canada Toronto Hosp Toronto ON Canada M5T 2S8 osurg, Toronto, ON M5T 2S8, Canada Univ Toronto, Toronto, ON M5T 2S8, Canada Univ Toronto Toronto ON Canada M5T 2S8 ronto, Toronto, ON M5T 2S8, Canada
Titolo Testata:
NEURO-ONCOLOGY
fascicolo: 1, volume: 3, anno: 2001,
pagine: 1 - 10
SICI:
1522-8517(200101)3:1<1:EAHROA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; RECEPTOR TYROSINE KINASE; VASCULAR-PERMEABILITY FACTOR; TUMOR ANGIOGENESIS; TIE2 RECEPTOR; UP-REGULATION; FACTOR VEGF; CELLS; RAS; GLIOMAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Guha, A 2-415 McLaughlin Pav,Western Div,UHN,399 Bathurst, Toronto, ON M5T2S8, Canada 2-415 McLaughlin Pav,Western Div,UHN,399 Bathurst Toronto ON Canada M5T 2S8
Citazione:
H. Ding et al., "Expression and hypoxic regulation of angiopoietins in human astrocytomas", NEURO-ONCOL, 3(1), 2001, pp. 1-10

Abstract

Vascular endothelial growth factor (VEGF) is a major inducer of tumor angiogenesis and edema in human astrocytomas by its interaction with cognate endothelial-specific receptors (VEGFR1/R2). Tie1 and Tie2/Tek are more recently identified endothelial-specific receptors, with angiopoietins being ligands for the latter. These angiogenic factors and receptors are crucial for the maturation of the vascular system, but their role in tumor angiogenesis, particularly in astrocytomas, is unknown. In this study, we demonstrate that the angiopoietin family member Ang1 is expressed by some of the astrocytoma cell lines. In contrast to VEGF, Ang1 is down regulated by hypoxia. Ang2 was not overexpressed. Expression profiles of low-grade astrocytoma specimens were similar to those of normal brain, with low levels of Ang1, Ang2,and VEGF expression. Glioblastoma multiforme expressed higher levels of Ang1, but not to the same degree as pseudopalisading astrocytoma cells aroundnecrotic and hypoxic zones expressed VEGF, as shown in previous studies. Ang2 expression in the highly proliferative tumor vascular endothelium was also increased, as was phosphorylated Tie2/Tek. The expression profile of these angiogenic factors and their endothelial cell receptors in human glioblastomas multiforme was similar to that in a transgenic mouse model of glioblastoma multiforme. These data suggest that both VEGF and angiopoietins areinvolved in regulating tumor angiogenesis in human astrocytomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 01:28:46