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Titolo:
Progesterone modulation of D5 receptor expression in hypothalamic ANP neurons, the role of estrogen
Autore:
Lee, D; Wang, L; Dong, P; Tran, T; Copolov, D; Lim, AT;
Indirizzi:
Mental Hlth Res Inst Victoria, Div Mol Schizophrenia, Helen Schutt Cell Biol Lab, Parkville, Vic 3052, Australia Mental Hlth Res Inst Victoria Parkville Vic Australia 3052 052, Australia Monash Univ, Dept Psychol Med, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 Med, Clayton, Vic 3168, Australia
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 1, volume: 6, anno: 2001,
pagine: 112 - 117
SICI:
1359-4184(200101)6:1<112:PMODRE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-FACTOR; RIBONUCLEIC-ACID EXPRESSION; MESSENGER-RNA EXPRESSION; PEPTIDE-(5-28) PRODUCTION; D1 RECEPTORS; RAT; SCHIZOPHRENIA; SECRETION; CULTURE; GLUCOCORTICOIDS;
Keywords:
estrogen; progesterone; dopamine D5 receptor; atrial natriuretic factor producing neurons; primary neuron cultures;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, D Mental Hlth Res Inst Victoria, Div Mol Schizophrenia, Helen Schutt Cell Biol Lab, 155 Oak St, Parkville, Vic 3052, Australia Mental Hlth Res Inst Victoria 155 Oak St Parkville Vic Australia 3052
Citazione:
D. Lee et al., "Progesterone modulation of D5 receptor expression in hypothalamic ANP neurons, the role of estrogen", MOL PSYCHI, 6(1), 2001, pp. 112-117

Abstract

Aberrant responses to dopamine consequent to a reduction of D-1-like receptors in critical regions of the brain have been implicated in schizophrenia. (1) Whereas estrogen may protect against the onset and incidence of psychosis in the illness, the neurobiological effects of the ovarian steroid remain unclear.(2-4) Recently we have shown that estrogen augments the expression of D-5 receptors, a member of the D-1-like receptor family, in central neurons and enhances the functions of the host cells.(5) Employing rat hypothalamic neuron cultures, we report here that another important ovarian steroid, progesterone, also augments dopamine D-5 receptor expression in hypothalamic atrial natriuretic factor (ANP) neurons. However, unlike the effect of estrogen, progesterone acts indirectly through potentiating estrogen-mediated changes that include enhancement of D-5 receptor expression, immunoreactive (ir)-ANP release and pro-ANP mRNA abundance. We conclude that whilstprogesterone has little effect by itself, the steroid works in synergism with estrogen to augment the function of ANP neurons. The possibility that progesterone may further enhance the protective effect of estrogen against the incidence of psychosis in schizophrenia now needs to be considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:42:36