Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Association study of the low-activity allele of catechol-O-methyltransferase and alcoholism using a family-based approach
Autore:
Wang, T; Franke, P; Neidt, H; Cichon, S; Knapp, M; Lichtermann, D; Maier, W; Propping, P; Nothen, MM;
Indirizzi:
Univ Bonn, Inst Human Genet, D-53111 Bonn, Germany Univ Bonn Bonn Germany D-53111 , Inst Human Genet, D-53111 Bonn, Germany Tongji Med Univ, Union Hosp, Dept Neurol, Wuhan 430022, Peoples R China Tongji Med Univ Wuhan Peoples R China 430022 han 430022, Peoples R China Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 onn, Dept Psychiat, D-53105 Bonn, Germany Inst Med Biometry Informat & Epidemiol, D-53105 Bonn, Germany Inst Med Biometry Informat & Epidemiol Bonn Germany D-53105 onn, Germany
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 1, volume: 6, anno: 2001,
pagine: 109 - 111
SICI:
1359-4184(200101)6:1<109:ASOTLA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE; COMT; POLYMORPHISM; INHERITANCE; VARIANT;
Keywords:
COMT; substance abuse; addiction; behavior genetics; candidate gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Nothen, MM Univ Bonn, Inst Human Genet, Wilhelmstr 31, D-53111 Bonn, Germany Univ Bonn Wilhelmstr 31 Bonn Germany D-53111 111 Bonn, Germany
Citazione:
T. Wang et al., "Association study of the low-activity allele of catechol-O-methyltransferase and alcoholism using a family-based approach", MOL PSYCHI, 6(1), 2001, pp. 109-111

Abstract

Catechol-O-methyltransferase (COMT) is a major component of the metabolic pathways of neurotransmitters such as dopamine, adrenaline, and noradrenaline. The activity of COMT is known to vary within the population; it exists in common high- and low-activity forms that are determined by a Val --> Metpolymorphism at amino acid position 108/158 (in soluble or membrane-bound COMT). Recently, the low-activity allele was reported to contribute to the development of late-onset alcoholism in men.(1) The present study extends this study by utilizing a family-based association approach, and by including individuals with early-onset alcoholism. Although no significant transmission disequilibrium was found in the overall sample of 70 parent/offspring trios (TDT = 1.43, P = 0.23), we observed a preferential transmission of the low-activity allele to patients with an early onset of disease (n = 32, TDT = 4.83, P = 0.028). Our results provide further evidence for an involvement of the COMT low-activity allele in the development of alcoholism and demonstrate the need for further studies in large samples of alcoholic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:27:36