Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Differential expression of diacylglycerol kinase iota and L18A mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding ANA rats
Autore:
Sommer, W; Arlinde, C; Caberlotto, L; Thorsell, A; Hyytia, P; Heilig, M;
Indirizzi:
Karolinska Inst, NEUROTEC, S-14186 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14186 UROTEC, S-14186 Huddinge, Sweden Natl Publ Hlth Inst, Dept Alcohol Res, Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland ept Alcohol Res, Helsinki, Finland
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 1, volume: 6, anno: 2001,
pagine: 103 - 108
SICI:
1359-4184(200101)6:1<103:DEODKI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROSS-FOSTERING ANALYSIS; RIBOSOMAL-PROTEIN L18A; DISPLAY; BINDING; ANXIETY; LINES;
Keywords:
gene expression; Wistar rats; anxiety; alcoholism; ribosomal protein; diacylglycerol kinase iota;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Sommer, W Huddinge Univ Hosp, Addict Ctr S, M 46, S-14186 Huddinge, SwedenHuddinge Univ Hosp M 46 Huddinge Sweden S-14186 uddinge, Sweden
Citazione:
W. Sommer et al., "Differential expression of diacylglycerol kinase iota and L18A mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding ANA rats", MOL PSYCHI, 6(1), 2001, pp. 103-108

Abstract

Ethanol preference and behavioral disinhibition in AA (alcohol accepting) animals is a behavioral constellation similar to that seen in human type IIalcoholism, for which considerable genetic loading has been shown. In search of novel neural substrates for this phenotype, we compared gene expression in the cerebral cortex of the AA rat with two groups of control animals,the ANA (alcohol non-accepting) line and heterogeneous Wistar animals, by differential display RT-PCR. We identified two transcripts, ribosomal protein L18a mRNA and diacyglycerol kinase iota mRNA, which are differentially expressed between AA and ANA rats. Ribosomal protein L18A mRNA is evenly expressed throughout the brain, but strongly reduced in cortex of AA rats vs controls, Diacylglycerol kinase iota is exclusively found in the brain, and expressed in a distinct regional pattern. Its cortical expression is about 25% higher in AA than ANA rats. Differential display RT-PCR seems to provide a feasible strategy to identify previously unknown genes whose differential expression correlates with behavioral phenotypes related to dependence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:37:17