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Titolo:
Protein kinase A and Rap1 levels in platelets of untreated patients with major depression
Autore:
Perez, J; Tardito, D; Racagni, G; Smeraldi, E; Zanardi, R;
Indirizzi:
Univ Milan, Sch Med, Dept Neuropsychiat Sci, Ist Sci H San Raffaele, I-20127 Milan, Italy Univ Milan Milan Italy I-20127 Sci H San Raffaele, I-20127 Milan, Italy Univ Milan, Inst Pharmacol Sci, Ctr Neuropharmacol, I-20133 Milan, Italy Univ Milan Milan Italy I-20133 Ctr Neuropharmacol, I-20133 Milan, Italy
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 1, volume: 6, anno: 2001,
pagine: 44 - 49
SICI:
1359-4184(200101)6:1<44:PKAARL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; ADENYLYL-CYCLASE ACTIVITY; POSTMORTEM BRAIN; MONONUCLEAR LEUKOCYTES; CYCLIC-AMP; MAP KINASE; ANTIDEPRESSANT TREATMENT; SIGNAL-TRANSDUCTION; BINDING PROTEINS; MOOD DISORDERS;
Keywords:
cAMP-signaling; PKA; Rap1; platelets; major depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Perez, J Univ Milan, Sch Med, Dept Neuropsychiat Sci, Ist Sci H San Raffaele, Via Stamira Ancona 20, I-20127 Milan, Italy Univ Milan Via Stamira Ancona 20 Milan Italy I-20127 ilan, Italy
Citazione:
J. Perez et al., "Protein kinase A and Rap1 levels in platelets of untreated patients with major depression", MOL PSYCHI, 6(1), 2001, pp. 44-49

Abstract

We have recently reported altered levels of protein kinase A and Rap1 in patients with bipolar disorder. The purpose of the current investigation wasto assess the levels of these proteins in platelets from untreated euthymic and depressed patients with major unipolar depression, Platelets were collected from 45 drug-free unipolar patients (13 euthymic and 32 depressed) and 45 healthy subjects. The levels of protein kinase A and Rap1 were assessed by Western blot analysis, immunostaining and computer-assisted imaging. The immunolabeling of the regulatory subunit type II of protein kinase A and that of Rap1 was significantly lower in untreated depressed patients compared with untreated euthymic patients and healthy subjects. No significant differences were found in the immunolabeling of both the regulatory type I and the catalytic subunits of protein kinase A among groups. Levers of the regulatory subunit type II of protein kinase A and Rap1 are altered in platelets of unipolar depressive patients. These findings may provide new insight about the relationship between components of cAMP signaling and affective disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 19:15:58