Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Ethanol acts synergistically with a D2 dopamine agonist to cause translocation of protein kinase C
Autore:
Gordon, AS; Yao, L; Jiang, Z; Fishburn, CS; Fuchs, S; Diamond, I;
Indirizzi:
Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, Emeryville, CA 94608 USA Univ Calif San Francisco Emeryville CA USA 94608 Emeryville, CA 94608 USA Univ Calif San Francisco, Dept Neurol, Emeryville, CA 94608 USA Univ CalifSan Francisco Emeryville CA USA 94608 Emeryville, CA 94608 USA Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, Emeryville, CA 94608 USA Univ Calif San Francisco Emeryville CA USA 94608 Emeryville, CA 94608 USA Univ Calif San Francisco, Grad Program Neurosci, Emeryville, CA 94608 USA Univ Calif San Francisco Emeryville CA USA 94608 Emeryville, CA 94608 USA Univ Calif San Francisco, Ctr Neurobiol Addict, Emeryville, CA 94608 USA Univ Calif San Francisco Emeryville CA USA 94608 Emeryville, CA 94608 USA Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 Chem, IL-76100 Rehovot, Israel Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 unol, IL-76100 Rehovot, Israel
Titolo Testata:
MOLECULAR PHARMACOLOGY
fascicolo: 1, volume: 59, anno: 2001,
pagine: 153 - 160
SICI:
0026-895X(200101)59:1<153:EASWAD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION; ANCHORING PROTEINS; D-2 RECEPTORS; CELL-LINES; EPSILON; MICE; INCREASES; EXPOSURE; LOCALIZATION; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Gordon, AS Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, 5858 Horton St,Suite 200, Emeryville, CA 94608 USA Univ Calif San Francisco 5858 Horton St,Suite 200 Emeryville CA USA 94608
Citazione:
A.S. Gordon et al., "Ethanol acts synergistically with a D2 dopamine agonist to cause translocation of protein kinase C", MOLEC PHARM, 59(1), 2001, pp. 153-160

Abstract

Ethanol and other drugs of abuse increase synaptic dopamine levels; however, little is known about how ethanol alters dopaminergic signaling. We havereported that ethanol induces translocation of delta and epsilon protein kinase C (PKC) in neural cells in culture. Using NG108-15 and Chinese hamster ovary cell lines that express the dopamine D2 receptor (D2R), we show here that the D2R agonist R(-)- 2,10,11-trihydroxy-N-propyl-noraporphine hydrobromide (NPA) also causes translocation of d and epsilon PKC to the same sites as ethanol-induced translocation. D2R agonist and ethanol-induced translocation of delta and epsilon PKC share a common pathway that is blocked bypertussis toxin and requires phospholipase C (PLC) activity. These data suggest that both D2R agonists and ethanol activate PLC via a trimeric G protein leading to production of diacylglycerol with subsequent activation and translocation of delta and epsilon PKC. Moreover, ethanol and NPA, when present together at low concentrations that alone are ineffective, act synergistically to cause translocation of delta and epsilon PKC. Our data suggest that ethanol causes translocation of delta and epsilon PKC but cells expressing the D2R, such as neurons in the nucleus accumbens, may be particularlysensitive to low concentrations of ethanol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 02:50:22