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Titolo:
ELEVATED SERUM LEVELS OF NEOPTERIN IN ADULT PATIENTS WITH POLYMYOSITIS DERMATOMYOSITIS/
Autore:
SAMSONOV MY; NASSONOV EL; TILZ GP; GEHT BM; DEMEL U; GURKINA GT; SHTUTMAN VZ; GUSEVA AG; WACHTER H; FUCHS D;
Indirizzi:
INNSBRUCK UNIV,INST MED CHEM & BIOCHEM,FRITZ PREGL STR 3 A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,INST MED CHEM & BIOCHEM A-6020 INNSBRUCK AUSTRIA CARDIOL RES CTR MOSCOW 121552 RUSSIA GRAZ UNIV,DEPT INTERNAL MED GRAZ AUSTRIA INST GEN PATHOL & PATHOPHYSIOL MOSCOW RUSSIA RUSSIAN ACAD MED SCI,INST RHEUMATOL MOSCOW 109801 RUSSIA
Titolo Testata:
British journal of rheumatology
fascicolo: 6, volume: 36, anno: 1997,
pagine: 656 - 660
SICI:
0263-7103(1997)36:6<656:ESLONI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLUBLE INTERLEUKIN-2 RECEPTORS; NECROSIS-FACTOR-ALPHA; HUMAN MUSCLE-CELLS; INCLUSION-BODY MYOSITIS; INTERFERON-GAMMA; POLYMYOSITIS-DERMATOMYOSITIS; DISEASE-ACTIVITY; INFLAMMATORY MYOPATHIES; MONONUCLEAR-CELLS; SCLERODERMA;
Keywords:
POLYMYOSITIS; DERMATOMYOSITIS; NEOPTERIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
M.Y. Samsonov et al., "ELEVATED SERUM LEVELS OF NEOPTERIN IN ADULT PATIENTS WITH POLYMYOSITIS DERMATOMYOSITIS/", British journal of rheumatology, 36(6), 1997, pp. 656-660

Abstract

We determined serum concentrations of neopterin, soluble tumour necrosis factor (55 kDa) receptor (sTNF-R) and soluble interleukin-2 receptor (sIL-2R) in plasma of 44 patients with polymyositis (PM)/dermatomyositis (DM), including 15 patients with primary PM, 13 patients with primary DM, and 16 patients with myositis and systemic sclerosis in overlap. Concentrations of neopterin, sTNF-R and sIL-2R were measured using commercially available immunoassays. Serum neopterin was increased in 35 of 44 PM/DM patients (80%), sTNF-R in 14 (32%) and sIL-2R in 18 (41%) patients, respectively. There were significant correlations between serum neopterin and sTNF-R, sIL-2R and erythrocyte sedimentation rate (all P < 0.001). Neopterin, as well as sTNF-R and sIL-2R, did not correlate with clinical (neuromuscular and activities of daily living scores) and laboratory (creatine kinase levels) manifestations of myositis. Increased serum levels of neopterin were associated with non-muscular manifestations of PM/DM. In conclusion, serum neopterin appears to be a useful laboratory marker for ongoing immune activation and global disease activity in PM/DM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:10:03