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Titolo:
Heterogeneous control of blood flow amongst different vascular beds
Autore:
Hill, CE; Phillips, JK; Sandow, SL;
Indirizzi:
Australian Natl Univ, John Curtin Sch Med Res, Div Neurosci, Auton SynapseGrp, Canberra, ACT 0200, Australia Australian Natl Univ Canberra ACT Australia 0200 rra, ACT 0200, Australia Murdoch Univ, Div Vet & Biomed Sci, Murdoch, WA 6150, Australia Murdoch Univ Murdoch WA Australia 6150 d Sci, Murdoch, WA 6150, Australia
Titolo Testata:
MEDICINAL RESEARCH REVIEWS
fascicolo: 1, volume: 21, anno: 2001,
pagine: 1 - 60
SICI:
0198-6325(200101)21:1<1:HCOBFA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; GENE-RELATED PEPTIDE; ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION; GAP JUNCTION CHANNELS; RAT HEPATIC-ARTERY; MUSCARINIC RECEPTOR SUBTYPES; FLUID SHEAR-STRESS; CA2+-ACTIVATED K+ CHANNELS; RABBIT MESENTERIC-ARTERY; SPONTANEOUSLY HYPERTENSIVE RATS;
Keywords:
receptors; connexins; gap junctions; vasoconstriction; vasodilation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
621
Recensione:
Indirizzi per estratti:
Indirizzo: Hill, CE Australian Natl Univ, John Curtin Sch Med Res, Div Neurosci, Auton SynapseGrp, Canberra, ACT 0200, Australia Australian Natl Univ Canberra ACT Australia 0200 0200, Australia
Citazione:
C.E. Hill et al., "Heterogeneous control of blood flow amongst different vascular beds", MED RES REV, 21(1), 2001, pp. 1-60

Abstract

The control and maintenance of vascular tone is due to a balance between vasoconstrictor and vasodilator pathways. Vasomotor responses to neural, metabolic and physical factors vary between vessels in different vascular beds, as well as along the same bed, particularly as vessels become smaller. These differences result from variation in the composition of neurotransmitters released by perivascular nerves, variation in the array and activation of receptor subtypes expressed in different vascular beds and variation in the signal transduction pathways activated in either the vascular smooth muscle or endothelial cells. As the study of vasomotor responses often requires pre-existing tone, some of the reported heterogeneity in the relative contributions of different vasodilator mechanisms may be compounded by different experimental conditions. Biochemical variations, such as the expression of ion channels, connexin subtypes and other important components of secondmessenger cascades, have been documented in the smooth muscle and endothelial cells in different parts of the body. Anatomical variations, in the presence and prevalence of gap junctions between smooth muscle cells, between endothelial cells and at myoendothelial gap junctions, between the two celllayers, have also been described, These factors will contribute further tothe heterogeneity in local and conducted responses. (C) 2000 John Wiley & Sons. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:11:57