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Titolo:
Local compliance effects on the global pressure-volume relationship in models of intracranial pressure dynamics
Autore:
Stevens, SA; Lakin, WD;
Indirizzi:
Univ Vermont, Dept Math & Stat, Burlington, VT 05401 USA Univ Vermont Burlington VT USA 05401 ath & Stat, Burlington, VT 05401 USA Univ Montana, Dept Math Sci, Missoula, MT 59812 USA Univ Montana MissoulaMT USA 59812 Dept Math Sci, Missoula, MT 59812 USA
Titolo Testata:
MATHEMATICAL AND COMPUTER MODELLING OF DYNAMICAL SYSTEMS
fascicolo: 4, volume: 6, anno: 2000,
pagine: 445 - 465
SICI:
1387-3954(200012)6:4<445:LCEOTG>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Keywords:
cerebrospinal fluid (CSF); lumped-parameter models; compliances; dynamic intracranial pressures;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Engineering, Computing & Technology
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Stevens, SA Univ Montana, Dept Math Sci, Missoula, MT 59812 USA Univ Montana Missoula MT USA 59812 ci, Missoula, MT 59812 USA
Citazione:
S.A. Stevens e W.D. Lakin, "Local compliance effects on the global pressure-volume relationship in models of intracranial pressure dynamics", MATH CO M D, 6(4), 2000, pp. 445-465

Abstract

The experimentally-measured pressure-volume relationship for the human intracranial system is a nonlinear 'S-shaped' curve with two pressure plateaus, a point of inflection, and a vertical asymptote at high pressures where all capacity for volume compensation is lost. In lumped-parameter mathematical models of the intracranial system, local compliance parameters relate volume adjustments to dynamic changes in pressure differences between adjacent model subunits. This work explores the relationship between the forms used for local model compliances and the calculated global pressure-volume relationship. It is shown that the experimentally-measured global relationshipcan be recovered using physiologically motivated expressions for the localcompliances at the interfaces between the venous-cerebrospinal fluid (CSF)subunits and arterial-CSF subunits in the model. Establishment of a consistent link between local model compliances and the physiological bulk pressure-volume relationship is essential if lumped-parameter models are to be capable of realistically predicting intracranial pressure dynamics.

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Documento generato il 22/01/20 alle ore 06:44:49