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Titolo:
Vascular angiogenesis and morphogenesis of the vascular tree: from cell biology to clinical findings
Autore:
Pepper, MS;
Indirizzi:
Ctr Med Univ Geneva, Dept Morphol, CH-1211 Geneva, Switzerland Ctr Med Univ Geneva Geneva Switzerland CH-1211 -1211 Geneva, Switzerland
Titolo Testata:
M S-MEDECINE SCIENCES
fascicolo: 12, volume: 16, anno: 2000,
pagine: 1378 - 1386
SICI:
0767-0974(200012)16:12<1378:VAAMOT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
FRE
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; ALPHA-V INTEGRINS; MATRIX METALLOPROTEINASES; CAVERNOUS MALFORMATIONS; CHROMOSOME 7Q; VASCULOGENESIS; MECHANISMS; CYTOKINES; RECEPTOR; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Pepper, MS Ctr Med Univ Geneva, Dept Morphol, 1 Rue Michel Servet, CH-1211Geneva, Switzerland Ctr Med Univ Geneva 1 Rue Michel Servet Geneva Switzerland CH-1211
Citazione:
M.S. Pepper, "Vascular angiogenesis and morphogenesis of the vascular tree: from cell biology to clinical findings", M S-MED SCI, 16(12), 2000, pp. 1378-1386

Abstract

Angiogenesis is a necessary requirement for the growth of normal and neoplastic tissues. Immature endothelial-lined tubes which arise during angiogenesis differentiate into capillaries or larger vessels such as arteries and veins. Interest in these processes has gained impeutus recently with the identification of novel mediators and their associated receptor tyrosine kinases. The early phase of` angioigenesis includes endothelial cell migration,proliferation and extracellular proteolysis, and is mediated in part by the vascular endothelial growth factor (VEGF) family. Reciprocal interactionsthen occur between pluripotent mesenchyma and endothelium, resulting in the differentation of pericytes and smooth muscle cells. These interactions are mediated by the transforming growth factor-beta (TGF-beta), platelet-derived growth factor (PDGF) and angiopoietin families. Fibroblast growth factors (FGF) have been implicated in the regulation of angiogenesis. Although a large body of evidence gained principally from gene deletion studies questions their role during development, a role during inflammatory and tumor angiogenesis cannot be excluded. A novel role in angiogenesis as well as specification of arterial and venous vascular segments has recently been attributed to certain members of the Ephrin family. Advances in our understanding of the mechanisms of angiogenesis, together with the accumulation of information on processes as diverse as postnatal growth, wound healing and tissue repair, tumorigenesis, diabetic retinopathy, fertility/sterility and vascular malformations, has provided new hope for novel therapeutic strategies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:54:19