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Titolo:
Adenovirus protein V induces redistribution of nucleolin and B23 from nucleolus to cytoplasm
Autore:
Matthews, DA;
Indirizzi:
Univ Leeds, St Jamess Univ Hosp, Mol Med Unit, Leeds LS9 7TF, W Yorkshire,England Univ Leeds Leeds W Yorkshire England LS9 7TF LS9 7TF, W Yorkshire,England
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 2, volume: 75, anno: 2001,
pagine: 1031 - 1038
SICI:
0022-538X(200101)75:2<1031:APVIRO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIV-1 REV PROTEIN; PRE-RIBOSOMAL-RNA; VIRUS TYPE-1 REV; AG-NOR PROTEINS; BINDING PROTEIN; LOCALIZATION; CELLS; INFECTION; NUCLEUS; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Matthews, DA Univ Leeds, St Jamess Univ Hosp, Mol Med Unit, Beckett St,Clin Sci Bldg, Leeds LS9 7TF, W Yorkshire, England Univ Leeds Beckett St,Clin Sci Bldg Leeds W Yorkshire England LS9 7TF
Citazione:
D.A. Matthews, "Adenovirus protein V induces redistribution of nucleolin and B23 from nucleolus to cytoplasm", J VIROLOGY, 75(2), 2001, pp. 1031-1038

Abstract

Adenovirus infection inhibits synthesis and processing of rRNA and redistributes nucleolar antigens, Adenovirus protein V associates with nucleoli ininfected cells. This study delineates regions of protein V independently capable of nucleolar targeting. Also, evidence is presented that protein V has the unique property of relocating nucleolin and B23 to the cytoplasm when transiently expressed on its own in uninfected cells. Point mutation analysis indicates a role for the C terminus of protein V in the redirection ofnucleolin and B23 to the cytoplasm. This is the first time an adenovirus protein has been shown to have a direct effect on nucleolar antigens in isolation from viral infection. Moreover, adenovirus protein V is the first protein demonstrated to be capable of redirecting nucleolin and B23 to the cytoplasm.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:32:26