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Titolo:
MRI correlates of dementia after first clinical ischemic stroke
Autore:
Pohjasvaara, T; Mantyla, R; Salonen, O; Aronen, HJ; Ylikoski, R; Hietanen, M; Kaste, M; Erkinjuntti, T;
Indirizzi:
Univ Helsinki, Cent Hosp, Dept Clin Neurosci, Memory Res Unit,HYKS, FIN-00029 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00029 KS, FIN-00029 Helsinki, Finland Univ Helsinki, Cent Hosp, Dept Clin Neurosci, Stroke Unit, FIN-00029 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00029 it, FIN-00029 Helsinki, Finland Univ Helsinki, Cent Hosp, Dept Radiol, FIN-00029 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00029 ol, FIN-00029 Helsinki, Finland Kuopio Univ Hosp, Dept Clin Radiol, SF-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland SF-70210 adiol, SF-70210 Kuopio, Finland
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1-2, volume: 181, anno: 2000,
pagine: 111 - 117
SICI:
0022-510X(200012)181:1-2<111:MCODAF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHITE-MATTER HYPERINTENSITIES; TEMPORAL-LOBE ATROPHY; ALZHEIMERS-DISEASE; VASCULAR DEMENTIA; POSTSTROKE COHORT; DETERMINANTS; PREVALENCE; DIAGNOSIS;
Keywords:
stroke; ischemic; dementia; magnetic resonance imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Erkinjuntti, T Univ Helsinki, Cent Hosp, Dept Clin Neurosci, Memory Res Unit,HYKS, POB 300, FIN-00029 Helsinki, Finland Univ Helsinki POB 300 Helsinki Finland FIN-00029 , Finland
Citazione:
T. Pohjasvaara et al., "MRI correlates of dementia after first clinical ischemic stroke", J NEUR SCI, 181(1-2), 2000, pp. 111-117

Abstract

Background and purpose: Dementia after first clinical stroke frequently has been found, but the clinical and radiological con elates have not been fully detailed. We examined magnetic resonance imaging (MRI) con-elates of dementia in a large well-defined series of patients with first clinical ischemic stroke. Methods: Detailed medical, neurological and neuropsychological examination was conducted 3 months after ischemic stroke for 273 patients with first clinical stroke from a consecutive series of 486 patients aged 55-85 years. MRI of the head categorised infarcts (type, site, side, number, volume), extent of white matter lesions (WMLs) and degree of atrophy. The DSM-III definition for dementia was used. Results: Dementia was diagnosed in79 (28.9%) of the patients with first clinical stroke. Volumes, numbers, distinct sites of infarcts, extent of WMLs and degree of atrophy were different for the demented and nondemented subjects. Logistic regression analysisshowed that the correlates of dementia included the combination of infarctfeatures (volume of infarcts in left-sided anterior corona radiata; OR 1.86), extent of WMLs (OR 1.37), medial temporal lobe atrophy (OR 3.4) and host factors (low education; OR 1.11). The additive effect of having more thanone correlate was detected (OR 2.53). Conclusions: Dementia occurring after first clinical stroke is frequent and not solely due to a single stroke, but contain a combination of infarcts features, extent of WMLs, medial temporal lobe atrophy and host factors reflecting more than one underlying pathology. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/11/20 alle ore 10:03:25