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Titolo:
In vivo models of myocardial ischemia and reperfusion injury - Applicationto drug discovery and evaluation
Autore:
Black, SC;
Indirizzi:
Pfizer Inc, Global Res & Dev, Dept Cardiovasc & Metab Dis, Groton, CT 06340 USA Pfizer Inc Groton CT USA 06340 rdiovasc & Metab Dis, Groton, CT 06340 USA
Titolo Testata:
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
fascicolo: 2, volume: 43, anno: 2000,
pagine: 153 - 167
SICI:
1056-8719(200003/04)43:2<153:IVMOMI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NA+-H+ EXCHANGE; HUMAN SUPEROXIDE-DISMUTASE; PLATELET-ACTIVATING-FACTOR; FREE-RADICAL GENERATION; LIMITS INFARCT SIZE; ISOLATED RAT-HEART; IN-VIVO; BLOOD-FLOW; POSTISCHEMIC REPERFUSION; INTRACORONARY ADENOSINE;
Keywords:
ischemia; reperfusion; neutrophil; sodium-hydrogen exchange; in vivo; infarct size; adenosine;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Black, SC Pfizer Inc, Global Res & Dev, Dept Cardiovasc & Metab Dis, Groton, CT 06340 USA Pfizer Inc Groton CT USA 06340 Metab Dis, Groton, CT 06340 USA
Citazione:
S.C. Black, "In vivo models of myocardial ischemia and reperfusion injury - Applicationto drug discovery and evaluation", J PHARM TOX, 43(2), 2000, pp. 153-167

Abstract

This review discusses the pharmacology of regional myocardial ischemia andreperfusion (I/R) injury and the utilization of in vivo animal models in the preclinical development of novel therapeutic compounds. The manuscript aims to provide an overview of a number of different cardioprotective strategies that have been successful from a preclinical perspective and to also present where possible results of clinical trials of the respective compounds. Myocardial ischemia reperfusion injury may be manifested as myocardial stunning, ventricular arrhythmias, coronary vascular dysfunction, or the development of a myocardial infarct. This review is principally concerned withpreclinical studies related to reduction of infarct size. The pathophysiology of the reperfusion injury process is complex, including primarily cellular and humoral components of inflammation, as well as myocellular ionic and metabolic disturbances. This review will discuss strategies directed at oxygen-derived free radicals, neutrophils, adenosine, and the sodium-hydrogen exchanger (NHE). The results of preclinical cardioprotective studies are influenced by the paradigm used therefore methodological considerations will also be presented where appropriate. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 20:58:27