Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Bone marrow transplantation for beta-thalassemia: The University of California San Francisco experience
Autore:
Mentzer, WC; Cowan, MJ;
Indirizzi:
Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
fascicolo: 6, volume: 22, anno: 2000,
pagine: 598 - 601
SICI:
1077-4114(200011/12)22:6<598:BMTFBT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEM-CELL TRANSPLANTATION; MIXED HEMATOPOIETIC CHIMERISM; IDENTICAL LITTERMATE DOGS; PHARMACOLOGICAL IMMUNOSUPPRESSION; HEMOGLOBINOPATHIES; IRRADIATION;
Keywords:
thalassemia; bone marrow transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Mentzer, WC San Francisco Gen Hosp, Room 331,Bldg 100,1001 Potrero Ave, San Francisco,CA 94110 USA San Francisco Gen Hosp Room 331,Bldg 100,1001 Potrero Ave San Francisco CA USA 94110
Citazione:
W.C. Mentzer e M.J. Cowan, "Bone marrow transplantation for beta-thalassemia: The University of California San Francisco experience", J PED H ONC, 22(6), 2000, pp. 598-601

Abstract

We report the results of allogeneic HLA-matched family donor stem cell transplantation in 17 North American children with beta -thalassemia major or hemoglobin E/beta -thalassemia who received transplants at the University of California San Francisco. Pretransplantation conditioning was with busulfan, cyclophosphamide, and antithymocyte globulin and graft-versus-host prophylaxis used cyclosporine, usually with added methotrexate. Twelve childrenare alive, well, and free of the clinical manifestations of thalassemia. Four experienced graft rejection and autologous recovery, and one died from complications shortly after transplantation. Overall survival was 94% and event-free survival 71%, results similar to those obtained by other transplantation centers. Improved conditioning regimes and enlargement of the donorpool will be needed to improve the outcome of transplantation and to make this treatment available to more children with thalassemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:39:17