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Titolo:
Accuracy of exercise testing in the assessment of the severity of myocardial ischemia as determined by means of technetium-99m tetrofosmin SPECT scintigraphy
Autore:
Galassi, AR; Azzarelli, S; Lupo, L; Mammana, C; Foti, R; Tamburino, C; Musumeci, S; Giuffrida, G;
Indirizzi:
Ferrarotto Hosp, Inst Cardiol, Catania, Italy Ferrarotto Hosp Catania Italy arotto Hosp, Inst Cardiol, Catania, Italy Univ Catania, Lecturership Med Stat, I-95124 Catania, Italy Univ Catania Catania Italy I-95124 ship Med Stat, I-95124 Catania, Italy Univ Catania, Chair Nucl Med, I-95124 Catania, Italy Univ Catania Catania Italy I-95124 hair Nucl Med, I-95124 Catania, Italy
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 6, volume: 7, anno: 2000,
pagine: 575 - 583
SICI:
1071-3581(200011/12)7:6<575:AOETIT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; ST-SEGMENT DEPRESSION; HEART-RATE ADJUSTMENT; EMISSION COMPUTED-TOMOGRAPHY; OXYGEN-CONSUMPTION; RATE INDEX; ROTATIONAL TOMOGRAPHY; ANGINA-PECTORIS; STABLE ANGINA; LEFT MAIN;
Keywords:
exercise testing; technetium-99m tetrofosmin single photon emission computed tomography myocardial scintigraphy; rate-pressure product; ST/heart rate index;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Galassi, AR Via Antonello da Messina 75, I-95021 Catania, Italy Via Antonello da Messina 75 Catania Italy I-95021 nia, Italy
Citazione:
A.R. Galassi et al., "Accuracy of exercise testing in the assessment of the severity of myocardial ischemia as determined by means of technetium-99m tetrofosmin SPECT scintigraphy", J NUCL CARD, 7(6), 2000, pp. 575-583

Abstract

Background. The separation of patients with suspected or known coronary artery disease into low- and high-risk subgroups by means of noninvasive testing is highly relevant in the selection of patients who require further diagnostic or therapeutic investigation. We evaluated whether exercise electrocardiographic variables during exercise testing might be a means of predicting the severity of myocardial ischemia as assessed,vith myocardial scintigraphy. Methods and Results. We retrospectively reviewed 816 consecutive patients (mean age, 57 +/- 10 Sears) who underwent exercise technetium-99m tetrofosmin single photon emission computed tomography (SPECT) for the assessment ofsuspected or known coronary artery disease, Eight independent significant predictors of the extent and severity of reversible perfusion defects (ischemic perfusion score), which when integrated in a diagnostic algorithm satisfactorily discriminated patients with no reversible perfusion defects (sensitivity, 75%; specificity, 80%) and patients with severe impaired myocardial perfusion (greater than or equal to 11 ischemic perfusion score; sensitivity, 77%; specificity, 82%), were identified by means of stepwise discriminant analysis. However, patients,vith mildly to moderately impaired myocardial perfusion (greater than or equal to1 but <11 ischemic perfusion score) were poorly discriminated (sensitivity, 50%; specificity, 78%), The set of variables that were significant (P <.0001) for prediction included sex, myocardial infarction, exercise angina, the maximal amount of ST segment depression, rate-pressure product threshold criteria, slope of ST segment depression, ST/heart rate index, and peak exercise heart rate. Conclusions. The results of the use of clinical and electrocardiographic exercise variables satisfactorily agrees with the results from scintigraphy only for patients with no reversible perfusion defects and with severely impaired myocardial perfusion. However, it fails as an approach with universal applicability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:01:58