Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Is abnormal iodine-123-MIBG kinetics associated with left ventricular dysfunction in patients with diabetes mellitus?
Autore:
Sugiyama, T; Kurata, C; Tawarahara, K; Nakano, T;
Indirizzi:
Hamamatsu Univ, Sch Med, Dept Med 3, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Hamamatsu Red Cross Hosp, Dept Internal Med, Hamamatsu, Shizuoka, Japan Hamamatsu Red Cross Hosp Hamamatsu Shizuoka Japan matsu, Shizuoka, Japan
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 6, volume: 7, anno: 2000,
pagine: 562 - 568
SICI:
1071-3581(200011/12)7:6<562:IAIKAW>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENERGIC CARDIAC INNERVATION; EMISSION COMPUTED-TOMOGRAPHY; AUTONOMIC NEUROPATHY; SYSTOLIC FUNCTION; HEART-DISEASE; EXERCISE; CARDIOMYOPATHY; RATS; METAIODOBENZYLGUANIDINE; ECHOCARDIOGRAPHY;
Keywords:
iodine-123-metaiodobenzylguanidine; diabetic cardiomyopathy; diabetes mellitus; cardiac sympathetic neuropathy; systolic dysfunction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Sugiyama, T Hamamatsu Univ, Sch Med, Dept Med 3, 3600 Handa Cho, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ 3600 Handa Cho Hamamatsu Shizuoka Japan 4313192
Citazione:
T. Sugiyama et al., "Is abnormal iodine-123-MIBG kinetics associated with left ventricular dysfunction in patients with diabetes mellitus?", J NUCL CARD, 7(6), 2000, pp. 562-568

Abstract

Background. Although autonomic neuropathy is frequently recognized in patients with diabetes mellitus, it is uncertain whether cardiac sympathetic neuropathy may play a role In the development of diabetic cardiomyopathy. Methods and Results. In 10 control subjects and 61 patients with diabetes mellitus who did not have coronary artery disease, cardiac sympathetic function and left ventricular ejection fraction (LVEF) were evaluated by using iodine-123 metaiodobenzylguanidine (MIBG) imaging and echocardiography, respectively Dynamic acquisitions and planar images obtained 15 and 150 minutes after injection were used as a means of measuring early and late myocardial uptake and clearance rates of MIBG from the heart. Eight patients with an LVEF less than 50% demonstrated a lower late myocardial MIBG uptake (0.0043 % +/- 0.0017 % vs 0.0024 % +/- 0.0009 %/pixel, P =.002) and a higher clearance rate (22.9% +/- 17.7% vs 49.3% +/- 12.2%, P <.0001) than the 53 patients with an LVEF of 50% or greater, although the age, sex, type of diabetes mellitus, and frequency of neuropathy, retinopathy, and nephropathy were not significantly different between the 2 subgroups. The LVEF correlated weakly but significantly with early and late myocardial uptake and clearance rate (r = 0.277, P =.03; r = 0.421, P =.001; r = 0.382, P =.002; respectively) in patients with diabetes mellitus. Conclusion. Marked MIBG abnormalities are associated with left ventriculardysfunction in patients with diabetes mellitus, However, long-term follow-up of patients with diabetes mellitus who have marked MIBG abnormalities and normal LVEF will be required to determine whether these patients would demonstrate systolic dysfunction earlier than patients without an MIBG abnormality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 18:39:11