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Titolo:
Aggressive behavior, increased accumbal dopamine, and decreased cortical serotonin in rats
Autore:
van Erp, AMM; Miczek, KA;
Indirizzi:
Tufts Univ, Dept Psychol, Medford, MA 02155 USA Tufts Univ Medford MA USA02155 Univ, Dept Psychol, Medford, MA 02155 USA Tufts Univ, Dept Psychiat, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 Univ, Dept Psychiat, Boston, MA 02111 USA Tufts Univ, Dept Pharmacol, Boston, MA 02111 USA Tufts Univ Boston MA USA02111 Univ, Dept Pharmacol, Boston, MA 02111 USA Tufts Univ, Dept Neurosci, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 Univ, Dept Neurosci, Boston, MA 02111 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 24, volume: 20, anno: 2000,
pagine: 9320 - 9325
SICI:
0270-6474(200012)20:24<9320:ABIADA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; MEDIAL PREOPTIC AREA; NUCLEUS-ACCUMBENS; EXTRACELLULAR DOPAMINE; 5-HYDROXYINDOLEACETIC ACID; IMPULSIVE AGGRESSION; INTRAVENOUS COCAINE; LIMBIC DOPAMINE; 5-HT1B RECEPTOR; D-AMPHETAMINE;
Keywords:
aggression; dopamine; serotonin; nucleus accumbens; prefrontal cortex; rats; microdialysis; behavior;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Miczek, KA Bacon Hall,530 Boston Ave, Medford, MA 02155 USA Bacon Hall,530 Boston Ave Medford MA USA 02155 d, MA 02155 USA
Citazione:
A.M.M. van Erp e K.A. Miczek, "Aggressive behavior, increased accumbal dopamine, and decreased cortical serotonin in rats", J NEUROSC, 20(24), 2000, pp. 9320-9325

Abstract

Dopamine (DA) and serotonin have been implicated in the regulation of aggressive behavior, but it has remained challenging to assess the dynamic changes in these neurotransmitters while aggressive behavior is in progress. The objective of this study was to learn about ongoing monoamine activity in corticolimbic areas during aggressive confrontations in rats. Male Long-Evans rats were implanted with a microdialysis probe aimed at the nucleus accumbens (NAC) or medial prefrontal cortex (PFC); next, 10 min samples were collected before, during, and after a 10 min confrontation. Rats continued todisplay aggressive behavior while being sampled, and they performed two tosix attack bites as well as 140 sec of aggressive acts and postures. Dopamine levels in NAC were significantly increased up to 60 min after the confrontation. Peak levels of 140% were achieved similar to 20-30 min after the confrontation. No concurrent changes in accumbal serotonin levels were seenduring or after the confrontation. Dopamine and serotonin levels in PFC changed in the opposite direction, with a sustained decrease in serotonin to 80% of baseline levels during and after the confrontation and an increase in dopamine to 120% after the confrontation. The temporal pattern of monoamine changes, which followed rather than preceded the confrontation, points to a significant role of accumbal and cortical DA and 5-hydroxytryptamine inthe consequences as opposed to the triggering of aggressive acts. The increase in accumbal DA in aggressive animals supports the hypothesis that thisneural system is linked to the execution of biologically salient and demanding behavior.

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Documento generato il 10/07/20 alle ore 14:01:20