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Titolo:
Protection against murine coxsackievirus B3 myocarditis by T cell vaccination
Autore:
Kishimoto, C; Takada, H; Hiraoka, Y; Shinohara, H; Kitazawa, M;
Indirizzi:
Toyama Med & Pharmaceut Univ, Fac Med, Dept Internal Med 2, Toyama 93001, Japan Toyama Med & Pharmaceut Univ Toyama Japan 93001 d 2, Toyama 93001, Japan Toyama Med & Pharmaceut Univ, Fac Med, Dept Human Sci, Toyama 93001, JapanToyama Med & Pharmaceut Univ Toyama Japan 93001 Sci, Toyama 93001, Japan Toyama Med & Pharmaceut Univ, Fac Med, Dept Pathol, Toyama 93001, Japan Toyama Med & Pharmaceut Univ Toyama Japan 93001 hol, Toyama 93001, Japan
Titolo Testata:
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
fascicolo: 12, volume: 32, anno: 2000,
pagine: 2269 - 2277
SICI:
0022-2828(200012)32:12<2269:PAMCBM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ACTIVATED KILLER-CELLS; INTERLEUKIN-2; THERAPY; SUPERANTIGENS; GLOBULIN; GAMMA; MICE;
Keywords:
coxsackievirus B3; T cell vaccination; lymphokine-activated killer cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kishimoto, C Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, 54 Kawara Cho, Kyoto 6068507, Japan Kyoto Univ 54 Kawara Cho Kyoto Japan 6068507 6068507, Japan
Citazione:
C. Kishimoto et al., "Protection against murine coxsackievirus B3 myocarditis by T cell vaccination", J MOL CEL C, 32(12), 2000, pp. 2269-2277

Abstract

T cell Vaccination regulates autoimmunity by the modification of helper and suppressor T cells. The present study was performed to examine whether T cell vaccination can prevent viral myocarditis in vivo. We used coxsackievirus B3 myocarditis in mice as an animal model with the analysis of lymphokine-activated killer cell activity. Vaccination of the mice with T lymphocytes significantly prolonged survival and improved cardiac histology of murine myocarditis. The effects of T cell vaccination were most evident when T cells sensitized with the same Virus were used. Vaccination of the mice withT cells from other strains of mice showed lesser protective effects. Clearance of myocardial Virus was not affected by this treatment. The efficacy of T cell vaccination was confirmed in vitro by the decrease of the lymphokine-activated killer cell activity against EL-4 tumor cells and cultured myocytes. T cell vaccination of mice prolonged survival and improved myocardial lesions of animals inoculated with coxsackievirus B3. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:37:00