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Titolo:
HLA-DQB1*0501-restricted Th1 type immune responses to Plasmodium falciparum liver stage antigen 1 protect against malaria anemia and reinfections
Autore:
May, J; Lell, B; Luty, AJF; Meyer, CG; Kremsner, PG;
Indirizzi:
Humboldt Univ, Inst Trop Med Berlin, D-14050 Berlin, Germany Humboldt Univ Berlin Germany D-14050 Med Berlin, D-14050 Berlin, Germany Humboldt Univ, Med Fak Charite, D-14050 Berlin, Germany Humboldt Univ Berlin Germany D-14050 ak Charite, D-14050 Berlin, Germany Univ Tubingen, Inst Trop Med, Sekt Humanparasitol, Tubingen, Germany Univ Tubingen Tubingen Germany , Sekt Humanparasitol, Tubingen, Germany Bernhard Nocht Inst Trop Med, Sekt Trop Med Grundlagenforsch, Hamburg, Germany Bernhard Nocht Inst Trop Med Hamburg Germany enforsch, Hamburg, Germany Hop Albert Schweitzer, Lab Rech, Lambarene, Gabon Hop Albert Schweitzer Lambarene Gabon itzer, Lab Rech, Lambarene, Gabon
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 1, volume: 183, anno: 2001,
pagine: 168 - 172
SICI:
0022-1899(20010101)183:1<168:HTTIRT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I; HLA; ASSOCIATION; RESISTANCE; VACCINE; HEPATOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: May, J Humboldt Univ, Inst Trop Med Berlin, Spandauer Damm 130, D-14050 Berlin, Germany Humboldt Univ Spandauer Damm 130 Berlin Germany D-14050 n, Germany
Citazione:
J. May et al., "HLA-DQB1*0501-restricted Th1 type immune responses to Plasmodium falciparum liver stage antigen 1 protect against malaria anemia and reinfections", J INFEC DIS, 183(1), 2001, pp. 168-172

Abstract

Protective immunity against Plasmodium falciparum requires constant exposure to the pathogen. T cell-mediated immune responses are induced by T cell epitopes of pre-erythrocytic stage antigens of P. falciparum and involve HLA-restricted CD4 and CD8 cells. Cytotoxic T cell responses to a conserved epitope of P. falciparum liver stage antigen (LSA) type 1 are restricted by the HLA class I allele Bw53. The role of HLA class II alleles in mediating cellular responses against P. falciparum LSA-1 has not yet been demonstrated. In a longitudinal study performed for >4 years, associations were found between the HLA class II allele DQB1* 0501 and protection from malaria anemia and malarial reinfections in Gabonese children. Children carrying DQB1* 0501 had a higher frequency of interferon-gamma responses to LSA-1 T cell epitopes, compared with noncarriers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:14:12