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Titolo:
Serum samples from infants vaccinated with a pneumococcal conjugate vaccine, PncT, protect mice against invasive infection caused by Streptococcus pneumoniae serotypes 6A and 6B
Autore:
Saeland, E; Jakobsen, H; Ingolfsdottir, G; Sigurdardottir, ST; Jonsdottir, I;
Indirizzi:
Lanspitali Univ Hosp, Dept Immunol, IS-101 Reykjavik, Iceland Lanspitali Univ Hosp Reykjavik Iceland IS-101 IS-101 Reykjavik, Iceland
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 2, volume: 183, anno: 2001,
pagine: 253 - 260
SICI:
0022-1899(20010115)183:2<253:SSFIVW>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPSULAR POLYSACCHARIDE VACCINE; ANTIBODY-RESPONSE; OTITIS-MEDIA; INTRANASAL IMMUNIZATION; CHILDREN; IMMUNOGENICITY; EFFICACY; EPIDEMIOLOGY; DISEASE; OPSONOPHAGOCYTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Jonsdottir, I Lanspitali Univ Hosp, Dept Immunol, IS-101 Reykjavik, Iceland Lanspitali Univ Hosp Reykjavik Iceland IS-101 vik, Iceland
Citazione:
E. Saeland et al., "Serum samples from infants vaccinated with a pneumococcal conjugate vaccine, PncT, protect mice against invasive infection caused by Streptococcus pneumoniae serotypes 6A and 6B", J INFEC DIS, 183(2), 2001, pp. 253-260

Abstract

Streptococcus pneumoniae serogroup 6 is an important cause of respiratory tract disease worldwide. Vaccination with 6B polysaccharide induces antibody response to the cross-reacting serotype 6A, but the protective capacity of 6A antibodies induced in infants remains unknown. In this study, passive immunization with serum samples obtained from infants vaccinated with an octavalent polysaccharide protein conjugate vaccine, PncT, protected mice against bacteremia and/or lung infection caused by intranasal challenge with serotypes 6B and 6A. Protective infant serum samples had significantly higher serotype-specific IgG levels and opsonic activity than did nonprotective serum samples. The protective level to either serotype was similar to1 mug of specific IgG antibodies injected per mouse (corresponding to similar to0.3 mug/mL). The protection was strongly related to opsonophagocytic antibody levels measured in vitro. These results demonstrate that PncT induces antibodies in infants that protect mice against invasive disease caused by thehomologous serotype and by the cross-reacting serotype 6A.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:59:26