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Titolo:
JC virus genotypes in France: Molecular epidemiology and potential significance for progressive multifocal leukoencephalopathy
Autore:
Dubois, V; Moret, H; Lafon, ME; Brodard, V; Icart, J; Ruffault, A; Guisthau, O; Buffet-Janvresse, C; Abbed, K; Dussaix, E; Ingrand, D;
Indirizzi:
Univ Bordeaux 2, Virol Lab EA 2968, F-33076 Bordeaux, France Univ Bordeaux2 Bordeaux France F-33076 A 2968, F-33076 Bordeaux, France CHU R Debre, Dept Microbiol, Reims, France CHU R Debre Reims FranceCHU R Debre, Dept Microbiol, Reims, France CHU Purpan, Virol Lab, Toulouse, France CHU Purpan Toulouse FranceCHU Purpan, Virol Lab, Toulouse, France CHU Pontchaillou, Virol Lab, Rennes, France CHU Pontchaillou Rennes France Pontchaillou, Virol Lab, Rennes, France CHU Rouen, Virol Lab, Rouen, France CHU Rouen Rouen FranceCHU Rouen, Virol Lab, Rouen, France CHU P Brousse, Virol Lab, Villejuif, France CHU P Brousse Villejuif France P Brousse, Virol Lab, Villejuif, France
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 2, volume: 183, anno: 2001,
pagine: 213 - 217
SICI:
0022-1899(20010115)183:2<213:JVGIFM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN POLYOMAVIRUS JC; DNA-SEQUENCE ANALYSIS; COMPLETE GENOMES; CEREBROSPINAL-FLUID; AIDS PATIENTS; BRAIN-TISSUE; BK-VIRUS; URINE; REARRANGEMENTS; INDIVIDUALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Lafon, ME Univ Bordeaux 2, Virol Lab EA 2968, 146 Rue Leo Saignat, F-33076Bordeaux,France Univ Bordeaux 2 146 Rue Leo Saignat Bordeaux France F-33076 nce
Citazione:
V. Dubois et al., "JC virus genotypes in France: Molecular epidemiology and potential significance for progressive multifocal leukoencephalopathy", J INFEC DIS, 183(2), 2001, pp. 213-217

Abstract

JC virus (JCV) induces progressive multifocal leukoencephalopathy (PML), especially in human immunodeficiency virus (HIV)-infected patients. AlthoughJCV genotypes have primarily been associated with geographic patterns, a distinctive neuropathogenicity was recently attributed to genotype 2. A multicenter study was conducted to describe the distribution of JCV genotypes in France and to investigate correlations between genotypes and PML. Genotypes were determined by sequencing 494 bp in the VP1 capsid gene. Peripheral JCV was studied in 65 urine samples from 43 HIV-infected patients and from 22 control subjects. Genotypes 1, 4, 2, and 3 were detected in 52.3%, 30.8%, 12.3%, and 4.6% of the samples, respectively. In 56 brain or cerebrospinal fluid samples, PML-associated JCV of genotypes 1, 2, 4, and 3 was found in 66%, 19.7%, 8.9%, and 5.4%, respectively. Infection with JCV genotypes 1 or 2 was correlated with PML (odds ratio, 3.29). On the other hand, infection with JCV genotype 4 could represent a lower risk for PML.

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Documento generato il 22/10/20 alle ore 00:37:34