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Titolo:
VCAM-1 activates phosphatidylinositol 3-kinase and induces p120(Cbl) phosphorylation in human airway smooth muscle cells
Autore:
Lazaar, AL; Krymskaya, VP; Das, SKP;
Indirizzi:
Univ Penn, Sch Med, Dept Med, Div Pulm Allergy & Crit Care Div, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Care Div, Philadelphia, PA 19104 USA Wistar Inst, Philadelphia, PA 19104 USA Wistar Inst Philadelphia PA USA 19104 ar Inst, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 1, volume: 166, anno: 2001,
pagine: 155 - 161
SICI:
0022-1767(20010101)166:1<155:VAP3AI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; INTEGRIN SIGNALING PATHWAY; HUMAN ENDOTHELIAL-CELLS; EPIDERMAL GROWTH-FACTOR; TYROSINE PHOSPHORYLATION; CROSS-LINKING; T-CELLS; PHOSPHOINOSITIDE 3-KINASE; ADAPTER PROTEIN; DNA-SYNTHESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Lazaar, AL Univ Penn, Sch Med, Dept Med, Div Pulm Allergy & Crit Care Div,852 BRB 2-3,421 Curie Blvd, Philadelphia, PA 19104 USA Univ Penn 852 BRB 2-3,421 Curie Blvd Philadelphia PA USA 19104
Citazione:
A.L. Lazaar et al., "VCAM-1 activates phosphatidylinositol 3-kinase and induces p120(Cbl) phosphorylation in human airway smooth muscle cells", J IMMUNOL, 166(1), 2001, pp. 155-161

Abstract

VCAM-1 is a member of the Ig superfamily of receptors the expression of which is up-regulated on human airway smooth muscle (ASM) cells following stimulation with inflammatory mediators. The function of these receptors in adhesion is well known, but there is growing recognition that they also possess "outside-in" signaling functions, such as cytoskeletal reorganization, calcium mobilization, and cytokine release. The present study examined the activation of extracellular signal-regulated kinase and phosphatidylinositol3-kinase (PUK) in ASM cells following VCAM-1 engagement, VCAM-1 ligation activated extracellular signal-regulated kinase 2 and resulted in increased expression of cyclin D1, yet there was neither p27(kip1) degradation nor anincrease in smooth muscle cell DNA synthesis. VCAM-1 ligation, however, augmented the proliferative response to submitogenic concentrations of epidermal growth factor, VCAM-1 engagement also stimulated a rapid increase in PI3K activity. This was associated with phosphorylation of the adapter protein p120(Cbl) and an increase in Cbl-associated PI3K activity. These studies suggest that VCAM-1 is linked to multiple signaling pathways in human ASM cells and may function to augment growth factor-induced responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 05:49:33