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Titolo:
Herbal hepatotoxicity: An expanding but poorly defined problem
Autore:
Chitturi, S; Farrell, GC;
Indirizzi:
Univ Sydney, Westmead Hosp, Westmead Millenium Inst, Storr Liver Unit, Westmead, NSW 2145, Australia Univ Sydney Westmead NSW Australia 2145 it, Westmead, NSW 2145, Australia
Titolo Testata:
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
fascicolo: 10, volume: 15, anno: 2000,
pagine: 1093 - 1099
SICI:
0815-9319(200010)15:10<1093:HHAEBP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENIGN PROSTATIC HYPERPLASIA; CHRONIC HEPATITIS-C; JIN BU HUAN; LIVER-TRANSPLANTATION; PENNYROYAL OIL; SAW PALMETTO; MEDICINE; TOXICITY; FAILURE; GERMANDER;
Keywords:
Chinese herbal drugs; herbal medicine; toxic hepatitis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Farrell, GC Univ Sydney, Westmead Hosp, Westmead Millenium Inst, Storr Liver Unit, Westmead, NSW 2145, Australia Univ Sydney Westmead NSW Australia 2145 , NSW 2145, Australia
Citazione:
S. Chitturi e G.C. Farrell, "Herbal hepatotoxicity: An expanding but poorly defined problem", J GASTR HEP, 15(10), 2000, pp. 1093-1099

Abstract

Alternative therapies, including herbal remedies, are popular in the general population and even more so among patients with liver disease. The use of such products is now well established in western society and is no longerconfined to traditional medicine practitioners in Asia, Africa and the Middle-East. Their perceived benefits remain generally unproven and concern about adverse effects is leading to closer scrutiny of these products. Herbalhepatotoxicity has been recognized for many years, but new agents are constantly being identified. The varied manifestations of liver injury include steatosis, acute and chronic hepatitis, hepatic fibrosis, zonal or diffuse hepatic necrosis, bile duct injury, veno-occlusive disease, acute liver failure requiring liver transplantation and carcinogenesis. Potential interactions between herbal medicines and conventional drugs may interfere with patient management. Concurrent use of such products is not often disclosed unless specifically sought after and can lead to perpetuation of the liver injury. The present review focuses on emerging herbal hepatotoxins, newer patterns of liver injury among the older agents and provides an updated tabulation of the adverse effects of major herbal hepatotoxins. Key issues of diagnosis and prevention of this growing problem are addressed. Continued public education, physician awareness and more stringent licensing are required to tackle this growing problem. (C) 2000 Blackwell Science Asia Pty Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 14:25:06