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Titolo:
Subregional organization of preoptic area/anterior hypothalamic projections to arousal-related monoaminergic cell groups
Autore:
Steininger, TL; Gong, H; McGinty, D; Szymusiak, R;
Indirizzi:
Vet Adm Greater Los Angeles Heath Care Syst, Sepulveda, CA 91343 USA Vet Adm Greater Los Angeles Heath Care Syst Sepulveda CA USA 91343 43 USA Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA Univ CalifLos Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA Univ Calif LosAngeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 4, volume: 429, anno: 2001,
pagine: 638 - 653
SICI:
0021-9967(20010122)429:4<638:SOOPAH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLEEP-WAKING DISCHARGE; RAT LOCUS-COERULEUS; EYE-MOVEMENT SLEEP; BARRINGTONS NUCLEUS; TUBEROMAMMILLARY NUCLEUS; HISTIDINE-DECARBOXYLASE; POSTERIOR HYPOTHALAMUS; HISTAMINERGIC NEURONS; BASAL FOREBRAIN; DIAGONAL BAND;
Keywords:
hypothalamus; anterograde tracing; biotinylated dextran; tuberomammillary nucleus; locus coeruleus; dorsal raphe nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Szymusiak, R Vet Adm Greater Los Angeles Heath Care Syst, Sepulveda, CA 91343 USA Vet Adm Greater Los Angeles Heath Care Syst Sepulveda CA USA 91343
Citazione:
T.L. Steininger et al., "Subregional organization of preoptic area/anterior hypothalamic projections to arousal-related monoaminergic cell groups", J COMP NEUR, 429(4), 2001, pp. 638-653

Abstract

Pathways mediating the generation and/or maintenance of sleep reside within the preoptic/ anterior hypothalamus (POAH). Reproduction, water balance, thermoregulation, and neuroendocrine functions are also associated with POAH, but it is not fully understood whether sleep is consolidated with these behavioral and physiological functions, or whether sleep-related circuitry is segregated from other POAH regions. Recent studies indicate that sleep mechanisms may be localized to the ventrolateral preoptic area (VLPO) and that this region sends inhibitory projections to walking/arousal-related neurons in the histaminergic tuberomammillary nucleus (TM), the noradrenergic locus coeruleus (LC), and the serotonergic dorsal raphe (DR). The present study is a quantitative investigation of preoptic area efferents to these monoaminergic groups. The results demonstrate that biotinylated dextran injections in the VLPO region reveal a robust innervation of TM that was as much as five times greater than innervation derived from other POAH subregions. The innervation of TM originated almost exclusively from injection sites inthe region of galanin neurons. VLPO projections to the LC were moderately dense and were greater than in other POAH regions except for equivalent input from the medial preoptic area. Projections to the dorsal raphe were equivalent to LC innervation and were generally two to three times greater fromVLPO than from other POAH regions, except for projections from the lateralpreoptic region, which were similar in magnitude. The rostral and caudal levels projected more to the TM, whereas the midrostral region of VLPO strongly innervated the LC core. These findings, with recent studies demonstrating medial and lateral extensions of the sleep-related VLPO neuronal group, indicate that descending arousal state control may be mediated by this specific galaninergic/gamma -aminobutyric acid (GABA)ergic cell group. J. Comp. Neural. 429:638-653, 2001. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 01/12/20 alle ore 16:46:46