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Titolo:
Benzodiazepines with different half-life and falling in a hospitalized population: the GIFA study
Autore:
Passaro, A; Volpato, S; Romagnoni, F; Manzoli, N; Zuliani, G; Fellin, R;
Indirizzi:
Univ Ferrara, Dept Internal Med 2, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 nternal Med 2, I-44100 Ferrara, Italy
Titolo Testata:
JOURNAL OF CLINICAL EPIDEMIOLOGY
fascicolo: 12, volume: 53, anno: 2000,
pagine: 1222 - 1229
SICI:
0895-4356(200012)53:12<1222:BWDHAF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NURSING-HOME RESIDENTS; HIP FRACTURE; RISK-FACTORS; PSYCHOTROPIC-DRUGS; VALIDATION; PEOPLE;
Keywords:
benzodiazepines; different half-life; risk factor; fall; hospitalized elderly population pharmacoepidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Fellin, R Univ Ferrara, Dept Internal Med 2, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 d 2, I-44100 Ferrara, Italy
Citazione:
A. Passaro et al., "Benzodiazepines with different half-life and falling in a hospitalized population: the GIFA study", J CLIN EPID, 53(12), 2000, pp. 1222-1229

Abstract

in recent years, the use of benzodiazepines has been recognized as an independent risk factor for fairs among the elderly. To evaluate the role of different types of benzodiazepines in determining falls in a hospitalized geriatric population, we conducted a prospective study among 7908 patients consecutively admitted in 58 clinical centers of the Gruppo Italiano di Farmacovigilanza nell'Anziano (GIFA), during an 8-month observation period (1991 and 1993). Over 70% of the patients were older than 65 years, 50% were women, and 23.6% had a benzodiazepine prescription during hospital stay. The number of patients who experienced one or more falls during follow-up was 174(2.2%) Sixty falls occurred among patients taking benzodiazepines (3.2%) and 114 (1.9%) among those who did not use benzodiazepines; the crude odds ratio for users versus non-users was 1.7 (95% CI 1.2-2.3). Multivariate logistic regression analysis showed that benzodiazepines with very short (OR 1.9; CI 1.03-3.3) and short half-life (OR 1.8; CI 1.2-2.8) were positively associated with fails during hospital stay. Patients who used other psychotropic agents (OR 2.3; CI 1.7-3.4). antidiabetic agents (OR 1.5; CI 1.03-2.2),patients with presence of cognitive impairment (OR 1.6; CI 1.08-2.3), highlevel of comorbidity (OR 1.7; CI 1.05-2.9), more advanced age (>80 years, OR 2.7, CI 1.5-4.7) and those who stayed in the hospital for 17 days or more (OR 2.1; CI 1.4-3.3) were also at a greater risk. These findings suggest that benzodiazepines with short and very short half-life are an important and independent risk factor for falls and their prescription to elderly hospitalized patients should be carefully evaluated. (C) 2000 Elsevier Science Inc. All rights resented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:36:22