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Titolo:
Antihypertensive monotherapy and cardiovascular responses to an acoustic startle stimulus
Autore:
Girard, A; Holand, S; Laude, D; Elghozi, JL;
Indirizzi:
Assistance Publ Hop Paris, Hop Necker, Assoc Claude Bernard, Ctr Pharmacol,Ctr Invest Clin, Paris, France Assistance Publ Hop Paris Paris France l,Ctr Invest Clin, Paris, France
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
fascicolo: 1, volume: 37, anno: 2001,
pagine: 101 - 107
SICI:
0160-2446(200101)37:1<101:AMACRT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; ARTERIAL-PRESSURE; SPECTRAL-ANALYSIS; ALERTING STIMULI; MENTAL STRESS; HEART-RATE; VARIABILITY; BLOCKADE;
Keywords:
startle reflex; alerting response; finger blood pressure; model flow; autonomic nervous systema; adrenergic receptors; AT(1)-receptor antagonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Elghozi, JL Hop Necker Enfants Malad, Serv Nephrol Adultes, Unite Pharmacol Clin, 149 Rue Sevres, F-75743 Paris 15, France Hop Necker Enfants Malad 149 Rue Sevres Paris France 15 rance
Citazione:
A. Girard et al., "Antihypertensive monotherapy and cardiovascular responses to an acoustic startle stimulus", J CARDIO PH, 37(1), 2001, pp. 101-107

Abstract

To determine contribution of the autonomic nervous system to cardiovascular reactivity to noise, acoustic startle stimulus (110 dB, 1-20 kHz, 0.150 s) was administered to 35 subjects (19 women, 16 men) with mild essential hypertension. Among these patients, 10 were unmedicated and 35 were receivinglong-term monotherapy (10 were taking 100 mg atenolol, 5 were taking 10 mgprazosin, and 10 were taking 50 mg losartan daily). Polygraphic recordingswere obtained in supine position. Blood pressure (BP) and heart rate (HR) levels were stable until the noise was administered. In the unmedicated group BP and HR were elevated during the first 10 s. BP returned to resting levels after this period. The calculated hemodynamic indexes showed a biphasic change in total peripheral resistance (TPR), with an overall vasoconstriction associated with the BP rise phase, preceding a delayed vasodilation. The lowest HR changes were observed in the P-blocker group with increases of6 beats/min and 3 beats/min after the first and second noise stimulations,compared with 10 beats/min and 5 beats/min in the unmedicated group. Prazosin significantly reduced the BP rises to 7 mm Hg and 6 mm Hg for systolic BP and diastolic BP after the first stimulation compared with 22 mm Hg and 17 mm Hg in the untreated group (p < 0.01). The second stimulation after prazosin determined -5 mm Hg and 1 mm Hg changes for systolic BP and diastolic BP respectively, compared to rises of 13 mmHg for systolic BP and 10 mmHgfor diastolic BP in the untreated group (p < 0.01). The hemodynamic percentage changes resulting from the first stimulation indicated prazosin markedly reduced the noise-induced rise in TPR (p < 0.05). No effect of P-blockerwas detectable using percentage changes. The rises in BP were amplified inthe losartan-treated subjects compared with the other groups. Because of alow resting TPR in this group, the percentage changes in TPR resulting from noise were amplified in the subjects treated with the AT, receptor antagonist. In conclusion the acoustic startle stimulus appeared as a simple and reliable procedure for inducing transient increases due to a rise in TPR. Cardiovascular responses differed according to the antihypertensive monotherapy, with a limited effect of noise in the prazosin-treated group.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:07:32