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Titolo:
Guanabenz, an antihypertensive centrally acting alpha(2)-agonist, suppresses morning elevations in aggregation of human platelets
Autore:
Hayashi, J; Sato, H; Tanaka, Y; Tokuue, J; Ishida, N; Watanabe, K; Kitamoto, K;
Indirizzi:
Kyorin Univ, Sch Med, Dept Med & Gerontol, Tokyo 181, Japan Kyorin Univ Tokyo Japan 181 h Med, Dept Med & Gerontol, Tokyo 181, Japan
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
fascicolo: 1, volume: 37, anno: 2001,
pagine: 89 - 93
SICI:
0160-2446(200101)37:1<89:GAACAA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-ADRENERGIC AGENTS; SUDDEN CARDIAC DEATH; ADENYLATE-CYCLASE; BLOOD-PRESSURE; ALPHA-2-ADRENOCEPTORS; CATECHOLAMINES; IMIDAZOLINE; RECEPTORS; AGGREGABILITY; ADRENALINE;
Keywords:
alpha(2)-agonist; guanabenz; platelet aggregability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Hayashi, J Kyorin Univ, Sch Med, Dept Med & Gerontol, Tokyo 181, Japan Kyorin Univ Tokyo Japan 181 Med & Gerontol, Tokyo 181, Japan
Citazione:
J. Hayashi et al., "Guanabenz, an antihypertensive centrally acting alpha(2)-agonist, suppresses morning elevations in aggregation of human platelets", J CARDIO PH, 37(1), 2001, pp. 89-93

Abstract

To determine whether the antihypertensive agent guanabenz affects the circadian rhythm in the hemorheologic properties of the platelet, we evaluated the aggregability of platelets collected from 11 healthy subjects in the morning and the evening after the oral administration of this agent, daily for 2 weeks. We analyzed platelet aggregation by the turbidimetric method. Inan in vitro study, guanabenz, 10 nM-100 muM, did not affect platelet aggregation, whereas epinephrine induced platelet aggregation at an EC50 of 1.5 muM. The healthy volunteers demonstrated a diurnal variation in platelet aggregability that was high in the morning and low in the evening (66 +/- 10%and 56 +/- 11% respectively, of the percent platelet aggregation induced by epinephrine). The same variation was seen with the platelet aggregation induced by adenosine diphosphate (ADP) (62 +/- 8% [morning] vs. 51 +/- 7% [evening]). After the administration of guanabenz, platelet aggregability wassignificantly reduced in the morning compared with that before drug administration, when platelet aggregation was induced by epinephrine (49 +/- 9%, p < 0.05) or ADP (48 <plus/minus> 7%, p < 0.05), although the plasma levelsof catecholamine were unchanged. A suppressive effect of guanabenz on platelet aggregability was observed in the evening, as the platelets were stimulated by epinephrine (38 <plus/minus> 9%, p < 0.05), but nut by ADP (49 <plus/minus> 5%). Findings suggest that guanabenz mainly suppressed the morning enhancement in platelet aggregability, which contributes to the formationof intravascular thrombi. Thus, in addition to its antihypertensive actions, guanabenz may help to reduce the risk of vascular accidents, which frequently occur in the morning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 03:18:53