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Titolo:
Positive inotropic effects of calcium sensitizers on normal and failing cardiac myocytes
Autore:
Tsutsui, H; Kinugawa, S; Ide, T; Hayashidani, S; Suematsu, N; Satoh, S; Nakamura, R; Egashira, K; Takeshita, A;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ed, Higashi Ku, Fukuoka 8128582, Japan
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
fascicolo: 1, volume: 37, anno: 2001,
pagine: 16 - 24
SICI:
0160-2446(200101)37:1<16:PIEOCS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HEART-FAILURE; FERRET VENTRICULAR MUSCLE; INTRACELLULAR CALCIUM; ISOMETRIC TENSION; CA2+ SENSITIVITY; MYOCARDIUM; AGENT; MYOFILAMENTS; EMD-53998; INTACT;
Keywords:
heart failure; contractile function; calcium; myocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Tsutsui, H Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku,3-1-1 Maidashi, Fukuoka 8128582, Japan Kyushu Univ 3-1-1 Maidashi FukuokaJapan 8128582 128582, Japan
Citazione:
H. Tsutsui et al., "Positive inotropic effects of calcium sensitizers on normal and failing cardiac myocytes", J CARDIO PH, 37(1), 2001, pp. 16-24

Abstract

Calcium sensitizers increase myocardial contractile function without affecting Ca2+ homeostasis, which might be beneficial in the treatment of patients with heart failure. However, it remains uncertain whether Ca sensitizersinduce quantitatively similar inotropic responses in control and failing hearts. To compare their effects in normal versus failing hearts at the cellular level, shortening mechanics and intracellular calcium ([Ca2+](i)) transient were simultaneously measured in the left ventricular myocytes isolated from normal dogs (n = 8) and dogs with rapid pacing-induced heart failure(n = 7). CGP 48506 and EMD 57033 exerted a positive inotropic effect in a dose (0.1-3 muM)-dependent manner in both normal and heart failure myocytes. The percent increase of cell shortening magnitude was comparable between the two groups. COP 48506 and EMD 57033 did not affect the diastolic cell length and resting [Ca2+](i) level. They did not affect the duration of [Ca2](i) transient dynamics. Thus Ca2+ sensitizers exerted comparable positiveinotropic effects without affecting the rest cell length and rest [Ca2+](i) in normal and heart failure myocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:16:42