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Titolo:
A TEM-2 beta-lactamase encoded on an active Tn1-like transposon in the genome of a clinical isolate of Stenotrophomonas maltophilia
Autore:
Avison, MB; von Heldreich, CJ; Higgins, CS; Bennett, PM; Walsh, TR;
Indirizzi:
Univ Bristol, Sch Med Sci, Bristol Ctr Antimicrobial Res & Evaluat, Dept Pathol & Microbiol, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD Bristol BS8 1TD, Avon, England
Titolo Testata:
Journal of antimicrobial chemotherapy
fascicolo: 6, volume: 46, anno: 2000,
pagine: 879 - 884
Fonte:
ISI
Lingua:
ENG
Soggetto:
XANTHOMONAS-MALTOPHILIA; SEQUENCE-ANALYSIS; PSEUDOMONAS-MALTOPHILIA; ANTIBIOTIC-RESISTANCE; ESCHERICHIA-COLI; PURIFICATION; AERUGINOSA; CLONING; STRAIN; TN3;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Avison, MB Univ Bristol, Sch Med Sci, Bristol Ctr Antimicrobial Res & Evaluat, Dept Pathol & Microbiol, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD 8 1TD, Avon, England
Citazione:
M.B. Avison et al., "A TEM-2 beta-lactamase encoded on an active Tn1-like transposon in the genome of a clinical isolate of Stenotrophomonas maltophilia", J ANTIMICRO, 46(6), 2000, pp. 879-884

Abstract

A constitutively expressed beta -lactamase gene from a clinical isolate ofStenotrophomonas maltophilia, J675Ia, has been cloned. Its DNA sequence isalmost identical to that of bla(TEM2) (one nucleotide change) and the expressed enzyme is a Bush type 2a penicillinase with an amino acid sequence identical to that of TEM-2, The bla(TEM) gene was present within a novel Tn1/Tn3-type transposon in the genome of isolate J675Ia and the transposon was able to mobilize bla(TEM) on to the broad host-range conjugative plasmid, R388. When transferred to an Escherichia coli recipient, R388::Tn conferred high-level ampicillin resistance. This represents the first identification of a TEM beta -lactamase in S. maltophilia and the first evidence that thisimportant clinical pathogen is able to act as a reservoir for mobile beta -lactamase genes in the hospital environment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:19:19