Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Suppression of cytochrome P450 1A1 and 4A1 gene expression in renal carcinomas of TSC2 gene mutant (Eker) rats
Autore:
Okamoto, T; Momose, S; Hino, O;
Indirizzi:
Inst Canc, Dept Expt Pathol, Tokyo 1708455, Japan Inst Canc Tokyo Japan 1708455 nc, Dept Expt Pathol, Tokyo 1708455, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 1, volume: 18, anno: 2001,
pagine: 147 - 149
SICI:
1019-6439(200101)18:1<147:SOCP1A>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-METABOLIZING-ENZYMES; HEME OXYGENASE; INHERITED CANCER; LIVER; MOUSE;
Keywords:
cytochrome P450; renal carcinoma; TSC2 gene; Ah receptor nuclear translocator; haemoxygenase-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Hino, O Inst Canc, Dept Expt Pathol, Tokyo 1708455, Japan Inst Canc Tokyo Japan 1708455 Expt Pathol, Tokyo 1708455, Japan
Citazione:
T. Okamoto et al., "Suppression of cytochrome P450 1A1 and 4A1 gene expression in renal carcinomas of TSC2 gene mutant (Eker) rats", INT J ONCOL, 18(1), 2001, pp. 147-149

Abstract

kidney, cytochrome P450 (CYP) is involved in arachidonic acid metabolism and the maintenance of homeostasis, but only scarce information is availableas to how CYP expression is altered in rodent renal carcinomas (RCs). TSC2gene mutant (Eker) rat RCs are an example of a Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. In the present study, the expression of CYP in Eker RCs was studied. In the normal kidney, CYP 1A1 and 4A1 mRNAs were expressed, but this expression was suppressed in spontaneously-induced Eker RCs and in cell line Lk9dL and Lk9dR. In Lk9dL and Lk9dR, Ah receptor nuclear translocator and haemoxygenase-1 mRNAs were expressed, but this expression was inconsistent in spontaneously-induced Eker RCs. The present results showed the suppression of CYP 1A1 and 4A1 mRNA expression in spontaneously-induced Eker RCs and this suppression indicates altered metabolic conditions in Eker RCs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:06:00