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Titolo:
Human pancreatic cancer cells express non-functional Fas receptors and counterattack lymphocytes by expressing Fas ligand; a potential mechanism for immune escape
Autore:
Elnemr, A; Ohta, T; Yachie, A; Kayahara, M; Kitagawa, H; Ninomiya, I; Fushida, S; Fujimura, T; Nishimura, GI; Shimizu, K; Miwa, K;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Surg 2, Kanazawa, Ishikawa 9200934, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9200934 wa, Ishikawa 9200934, Japan Kanazawa Univ, Sch Med, Dept Pediat, Kanazawa, Ishikawa 9200934, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9200934 wa, Ishikawa 9200934, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 1, volume: 18, anno: 2001,
pagine: 33 - 39
SICI:
1019-6439(200101)18:1<33:HPCCEN>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED APOPTOSIS; COLORECTAL-CANCER; MOLECULAR-CLONING; LIVER METASTASES; ANTI-FAS; MEMBER; ADENOCARCINOMAS; CYTOTOXICITY; SUPERFAMILY; CARCINOMAS;
Keywords:
pancreatic cancer; Fas-mediated apoptosis; counterattack;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ohta, T Kanazawa Univ, Sch Med, Dept Surg 2, Takara Machi 13-1, Kanazawa, Ishikawa9200934, Japan Kanazawa Univ Takara Machi 13-1 Kanazawa Ishikawa Japan 9200934 an
Citazione:
A. Elnemr et al., "Human pancreatic cancer cells express non-functional Fas receptors and counterattack lymphocytes by expressing Fas ligand; a potential mechanism for immune escape", INT J ONCOL, 18(1), 2001, pp. 33-39

Abstract

The aim of this study was to investigate the expression and functional status of Fas ligand (FasL) and its receptor (Fas) in human pancreatic cancers. Using RT-PCR: and Western blotting, Fas and FasL were expressed in seven surgically resected pancreatic cancer specimens and five cell lines; Capan-1, AsPC-1, BxPC-3, PANC-1, and MIA PaCa-2. In the resected specimens, pancreatic cancer cells induced apoptosis in the surrounding lymphoid cells. In coculture experiments of pancreatic cancer and Jurkat T cells, 50% of Jurkat T cells underwent apoptosis after 2 days, however, almost all pancreatic cancer cells remained viable. In addition, by testing Fas function using anti-Fas antibody (CH11), all cell lines were resistant to Pas-mediated apoptosis except Capan-1 cells which showed sensitivity similar to that of Jurkat T cells. These results suggest that pancreatic cancer cells evade immune surveillance by expression of FasL and non-functioning Fas that allow them to 'counterattack' activated T-cells. These tumor escape mechanisms may contribute to the rapid fatal course of pancreatic cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 23:02:38