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Titolo:
Zaltoprofen prevents carbon tetrachloride-induced reduction of body weightin rats
Autore:
Okamoto, T; Masuda, Y; Kawasaki, T; Okabe, S;
Indirizzi:
Nippon Chemiphar Co Ltd, Res Labs, Misato, Saitama 3410005, Japan Nippon Chemiphar Co Ltd Misato Saitama Japan 3410005 itama 3410005, Japan Kyoto Pharmaceut Univ, Dept Appl Pharmacol, Kyoto 6078414, Japan Kyoto Pharmaceut Univ Kyoto Japan 6078414 harmacol, Kyoto 6078414, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 1, volume: 7, anno: 2001,
pagine: 101 - 104
SICI:
1107-3756(200101)7:1<101:ZPCTRO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MEGESTROL-ACETATE; GENE-EXPRESSION; CANCER; INTERLEUKIN-1-BETA; ANOREXIA; LIVER;
Keywords:
body weight loss; food intake; anorexia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Okamoto, T Nippon Chemiphar Co Ltd, Res Labs, 1-22 Hikokawato, Misato, Saitama 3410005, Japan Nippon Chemiphar Co Ltd 1-22 Hikokawato Misato Saitama Japan 3410005
Citazione:
T. Okamoto et al., "Zaltoprofen prevents carbon tetrachloride-induced reduction of body weightin rats", INT J MOL M, 7(1), 2001, pp. 101-104

Abstract

Previously we reported carbon tetrachloride-induced body weight loss in rats as a new model of wasting disorders. The oral administration of a low dose of carbon tetrachloride to rats reduced the body weight and food intake at 24 h with a minimal effect on plasma alanine aminotransferase activity. Tumor necrosis factor-alpha, and cyclooxygense-1 and -2 mRNA expression in the brain was not affected by carbon tetrachloride. Zaltoprofen, which is anon-steroidal antiinflammatory drug, prevented the carbon tetrachloride-induced body weight decrease, without preventing the carbon tetrachloride-induced loss of food intake. The present results suggest the possible application of this drug for the treatment of wasting disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:27:37