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Titolo:
The CD81 expression in liver in hepatocellular carcinoma
Autore:
Inoue, G; Horiike, N; Onji, M;
Indirizzi:
Ehime Univ, Sch Med, Dept Internal Med 3, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 1, volume: 7, anno: 2001,
pagine: 67 - 71
SICI:
1107-3756(200101)7:1<67:TCEILI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATITIS-C VIRUS; SIGNAL-TRANSDUCTION; KAI1/CD82 EXPRESSION; CORE PROTEIN; CANCER; MOTILITY; METASTASIS; MRP-1/CD9; ANTIBODY; TAPA-1;
Keywords:
CD81; hepatocellular carcinoma; hepatitis C virus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Horiike, N Ehime Univ, Sch Med, Dept Internal Med 3, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Ehime 7910295, Japan
Citazione:
G. Inoue et al., "The CD81 expression in liver in hepatocellular carcinoma", INT J MOL M, 7(1), 2001, pp. 67-71

Abstract

The expression of CD81, a cell receptor for hepatitis C virus, was examined on cancer cells in hepatocellular carcinoma (HCC) C (n=29) to clarify itsclinical role. CD81 was expressed on hepatocyte membrane in non-tumor portions in all patients, however, this was not stained on the cancer cell membranes in 6 of 29. Reverse transcriptase-PCR revealed that CD81 gene expression was not detected in the tumorous portions in 3 of 7 samples. The loss of CD81 was prominent in poorly differentiated HCC (5 of 8) and extrahepaticmetastasis patients (6 of 8). The loss of CD81 is associated with differentiation and metastasis of HCC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:04:25