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Titolo:
Effects of interaction between parvovirus minute virus of mice NS1 and coactivator CBP on NS1-and p53-transactivation
Autore:
Ohshima, T; Yoshida, E; Nakajima, T; Yagami, KI; Fukamizu, A;
Indirizzi:
Inst Appl Biochem, Ctr Tsukuba Adv Res Alliance, Tsukuba, Ibaraki 3058577,Japan Inst Appl Biochem Tsukuba Ibaraki Japan 3058577 ba, Ibaraki 3058577,Japan Univ Tsukuba, Inst Basic Med Sci, Tsukuba, Ibaraki 305, Japan Univ Tsukuba Tsukuba Ibaraki Japan 305 d Sci, Tsukuba, Ibaraki 305, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 1, volume: 7, anno: 2001,
pagine: 49 - 54
SICI:
1107-3756(200101)7:1<49:EOIBPM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CYCLE ARREST; TRANSCRIPTIONAL ACTIVATION; GENE-TRANSCRIPTION; H-1 PARVOVIRUS; P38 PROMOTER; PROTEIN; BINDING; E1A; TRANSACTIVATION; CREB;
Keywords:
NS1; CBP; coactivator; transcription factor; transactivation; parvovirus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Fukamizu, A Inst Appl Biochem, Ctr Tsukuba Adv Res Alliance, Tsukuba, Ibaraki 3058577,Japan Inst Appl Biochem Tsukuba Ibaraki Japan 3058577 3058577,Japan
Citazione:
T. Ohshima et al., "Effects of interaction between parvovirus minute virus of mice NS1 and coactivator CBP on NS1-and p53-transactivation", INT J MOL M, 7(1), 2001, pp. 49-54

Abstract

The non-structural protein NS1, encoded by the parvovirus minute virus of mice (MVM), is a potent regulator of viral gene expression in addition to prominent roles in viral replication and cytopathic effects associated with parvoviral infection. Although NS1 involves the modulation of viral and cellular transcription, the primary activation mechanism of MVM NS1 remains unclear. In the present study, we show here that the coactivator CREB bindingprotein, CBP, could potentiate NS1-mediated transcription as measured on the P38 promoter, which drives expression of the MVM capsid genes. NS1 boundto the two related cysteine-histidine-rich regions of CBP, referred to as C/H1 and C/H3, the former of which has an antagonistic function to CBP uponthe NS1-transactivation. Furthermore, NS1 inhibited the synergistic transactivation by CBP and p53. These findings suggested that CBP as a transcriptional coactivator is required for NS1-mediated viral and cellular transcription in parvovirus-infected cells, resulting in cell proliferation and differentiation to achieve its lytic cycle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/18 alle ore 02:12:53