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Titolo:
A detailed deletion map of chromosome 20 in human oral squamous cell carcinoma
Autore:
Imai, FL; Uzawa, K; Miyakawa, A; Shiiba, M; Tanzawa, H;
Indirizzi:
Chiba Univ, Sch Med, Dept Oral Surg, Chuo Ku, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 Oral Surg, Chuo Ku, Chiba 2608670, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 1, volume: 7, anno: 2001,
pagine: 43 - 47
SICI:
1107-3756(200101)7:1<43:ADDMOC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE GENOMIC HYBRIDIZATION; SUPPRESSOR GENE LOCI; TUMOR-SUPPRESSOR; MYELOPROLIFERATIVE DISORDERS; MYELODYSPLASTIC SYNDROMES; ALLELIC LOSS; LONG ARM; CANCER; HEAD; LOCALIZATION;
Keywords:
chromosome 20; loss of heterozygosity; oral squamous cell carcinoma; tumor suppressor gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Tanzawa, H Chiba Univ, Sch Med, Dept Oral Surg, Chuo Ku, 1-8-1 Inohana, Chiba 2608670, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 2608670 ba 2608670, Japan
Citazione:
F.L. Imai et al., "A detailed deletion map of chromosome 20 in human oral squamous cell carcinoma", INT J MOL M, 7(1), 2001, pp. 43-47

Abstract

Loss of heterozygosity (LOH) on the long arm of chromosome 20 (20q) has been detected in several human cancers. However, little is known about LOH onchromosome 20 in oral squamous cell carcinoma (OSCC). To determine which loci of chromosome 20 were involved in OSCC tumorigenesis, 41 cases of OSCC were examined for LOH state on chromosome 20 at 17 microsatellite loci by PCR-LOH assay. LOH occurred in 41.5% of tumors in at least one locus. Among the 17 loci, D20S48 on 20p11.2 and RPN2 on 20q12-13.1 exhibited higher frequencies of LOH, 27.6% and 31.4%, respectively. The LOH incidence was significantly higher in tumors in which the primary site was on gingiva compared with other oral sites (p=0.012). Our results indicate that allelic deletions on 20q12-13.1 and 20p11.2 may play roles in OSCC carcinogenesis, and suggest that allelic deletions on 20q might have some relation with the primarysite of OSCC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 12:40:29