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Titolo:
Lead exposure alters Egr-1 DNA-binding in the neonatal rat brain
Autore:
Reddy, GR; Zawia, NH;
Indirizzi:
Univ Rhode Isl, Dept Biomed Sci, Kingston, RI 02881 USA Univ Rhode Isl Kingston RI USA 02881 t Biomed Sci, Kingston, RI 02881 USA Savannah State Univ, Dept Biol & Life Sci, Savannah, GA 31404 USA SavannahState Univ Savannah GA USA 31404 ife Sci, Savannah, GA 31404 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
fascicolo: 8, volume: 18, anno: 2000,
pagine: 791 - 795
SICI:
0736-5748(200012)18:8<791:LEAEDI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; GENE-EXPRESSION; MESSENGER-RNA; PC12D CELLS; MECHANISMS; ZIF268; NEUROTOXICITY; CEREBELLUM; PROMOTER; SP1;
Keywords:
Egr-1; DNA-binding; zinc finger; lead (Pb);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Zawia, NH Univ Rhode Isl, Dept Biomed Sci, Kingston, RI 02881 USA Univ Rhode Isl Kingston RI USA 02881 ci, Kingston, RI 02881 USA
Citazione:
G.R. Reddy e N.H. Zawia, "Lead exposure alters Egr-1 DNA-binding in the neonatal rat brain", INT J DEV N, 18(8), 2000, pp. 791-795

Abstract

Zinc finger proteins (ZFP) contain a structural motif (Cys-2 His-2) found in a large family of eukaryotic transcriptional regulatory proteins, such as Spl. Previous studies have shown that Spl DNA-binding was disrupted by exposure to lead (Pb), due to action on its zinc finger domain. In this paper, we discuss the results of studies with another ZFP, Egr-1, an early growth response gene, which is functionally involved in cell proliferation and differentiation. Egr-1 DNA-binding was studied by gel shift mobility assays in several brain regions of developing rat pups. We observed a distinct developmental profile of Egr-1 DNA-binding with a gradual increase from the early to late postnatal days in all the brain regions examined. Lactational exposure to Pb resulted in a modulation of Egr-1 DNA binding manifested by premature peaks in DNA-binding reminiscent of the in vivo changes previouslyreported for Spl. These data are consistent with earlier findings that exposure to Pb both in vivo and in vitro causes a modulation ill the DNA-binding of ZFP such as Spl, Egr-1 and TFIIIA. The commonality by which Pb exposure alters the DNA-binding patterns of ZFP suggests that divalent Pb may be interacting directly with the Zn moiety of these proteins. (C) 2000 ISDN. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 18:31:39