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Titolo:
Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses
Autore:
Rigano, R; Profumo, E; Bruschi, F; Carulli, G; Azzara, A; Ioppolo, S; Buttari, B; Ortona, E; Margutti, P; Teggi, A; Siracusano, A;
Indirizzi:
Univ Rome La Sapienza, Ist Super Sanita, Dept Immunol, I-00161 Rome, ItalyUniv Rome La Sapienza Rome Italy I-00161 pt Immunol, I-00161 Rome, Italy Univ Rome La Sapienza, CNR, Inst Biomed Technol, I-00161 Rome, Italy Univ Rome La Sapienza Rome Italy I-00161 ed Technol, I-00161 Rome, Italy Univ Rome La Sapienza, Dept Infect & Trop Dis, I-00161 Rome, Italy Univ Rome La Sapienza Rome Italy I-00161 & Trop Dis, I-00161 Rome, Italy Univ Pisa, BMIE, Dept Expt Pathol, Pisa, Italy Univ Pisa Pisa ItalyUniv Pisa, BMIE, Dept Expt Pathol, Pisa, Italy Univ Pisa, Div Hematol, Dept Oncol, Pisa, Italy Univ Pisa Pisa ItalyUniv Pisa, Div Hematol, Dept Oncol, Pisa, Italy
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 1, volume: 69, anno: 2001,
pagine: 288 - 296
SICI:
0019-9567(200101)69:1<288:MOHIRB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD MONONUCLEAR-CELLS; HYDATID PATIENTS; CYST FLUID; EXPRESSION; CYTOKINE; NEUTROPHILS; MOTILITY; DISEASE; PROTOSCOLECES; EXPLOITATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Siracusano, A Univ Rome La Sapienza, Ist Super Sanita, Dept Immunol, VialeRegina Elena 299, I-00161 Rome, Italy Univ Rome La Sapienza Viale Regina Elena 299 Rome Italy I-00161
Citazione:
R. Rigano et al., "Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses", INFEC IMMUN, 69(1), 2001, pp. 288-296

Abstract

By directly suppressing the function of certain immune cell subsets and bystimulating other cell populations related to immunopathology, parasite-derived substances play an important role in the chronic establishment of parasitic disease. Our objective was twofold: (i) to investigate further the role of Echinococcus granulosus antigen B (AgB) in the human early inflammatory response by determining its effect on polymorphonuclear cell (PMN) random migration, chemotaxis, and oxidative metabolism and (ii) to determine its action in acquired immunity by evaluating AgB and sheep hydatid fluid (SHF)-driven Th1 (gamma interferon [IFN-gamma] and interleukin 12 [IL-12]) andTh2 (IL-4 and IL-13) cytokine production by peripheral blood mononuclear cells (PBMC) from 40 patients who had cured or stable or progressive cystic echinococcosis. AgB significantly inhibited PMN recruitment but left their random migration and oxidative metabolism unchanged. Patients' PBMC stimulated with AgB produced IL-4 and IL-13 but did not produce IL-12. They also produced significantly lower IFN-gamma concentrations than did PBMC stimulated with SHF (P = 10(-5)). AgB skewed the Th1/Th2 cytokine ratios towards a preferentially immunopathology-associated Th2 polarization, predominantly in patients with progressive disease. AgB-stimulated patients' PBMC also proliferated less than SHF-stimulated PBMC (P = 9 x 10(-3)). In vitro Th2 cytokine production was reflected in vivo by elevated specific immunoglobulin E(IgE) and IgG4 antibodies binding to AgB. These findings confirm that AgB plays a role in the escape from early immunity by inhibiting PMN chemotaxis. They also add new information on the host-parasite relationship, suggesting that AgB exploits the activation of T helper cells by eliciting a nonprotective Th2 cell response.

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Documento generato il 25/11/20 alle ore 04:17:43