Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of genetic resistance in invasive pneumococcal infection: Identification and study of susceptibility and resistance in inbred mouse strains
Autore:
Gingles, NA; Alexander, JE; Kadioglu, A; Andrew, PW; Kerr, A; Mitchell, TJ; Hopes, E; Denny, P; Brown, S; Jones, HB; Little, S; Booth, GC; McPheat, WL;
Indirizzi:
Univ Leicester, Dept Microbiol & Immunol, Leicester LE1 9HN, Leics, England Univ Leicester Leicester Leics England LE1 9HN er LE1 9HN, Leics, England Univ Glasgow, Div Infect & Immun, Glasgow G12 8QQ, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G12 8QQ ow G12 8QQ, Lanark, Scotland MRC, Mouse Genome Ctr, Harwell, Berks, England MRC Harwell Berks EnglandMRC, Mouse Genome Ctr, Harwell, Berks, England AstraZeneca Plc, Alderley Edge, England AstraZeneca Plc Alderley Edge England eneca Plc, Alderley Edge, England
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 1, volume: 69, anno: 2001,
pagine: 426 - 434
SICI:
0019-9567(200101)69:1<426:ROGRII>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-PHOSPHOCHOLINE ANTIBODIES; STREPTOCOCCUS-PNEUMONIAE; CRYPTOCOCCUS-NEOFORMANS; NATURAL-RESISTANCE; MICE; HOST; INFLAMMATION; PATHOGENESIS; PNEUMOLYSIN; RECRUITMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Andrew, PW Univ Leicester, Dept Microbiol & Immunol, POB 138,Med Sci Bldg,Univ Rd, Leicester LE1 9HN, Leics, England Univ Leicester POB 138,Med Sci Bldg,Univ Rd Leicester Leics England LE1 9HN
Citazione:
N.A. Gingles et al., "Role of genetic resistance in invasive pneumococcal infection: Identification and study of susceptibility and resistance in inbred mouse strains", INFEC IMMUN, 69(1), 2001, pp. 426-434

Abstract

From a panel of nine inbred mice strains intranasally infected with Streptococcus pneumoniae type 2 strain, BALB/c mice were resistant and CBA/Ca andSJL mice were susceptible to infection. Further investigation revealed that BALB/c mice were able to prevent proliferation of pneumococci in the lungs and blood, whereas CBA/Ca mice showed no bacterial clearance. Rapidly increasing numbers of bacteria in the blood was a feature of CBA/Ca but not BALB/c mice. In the lungs, BALB/c mice recruited significantly more neutrophils than CBA/Ca mice at 12 and 24 h postinfection. Inflammatory lesions in BALB/c mice were visible much earlier than in CBA/Ca mice, and there was a greater cellular infiltration into the lung tissue of BALB/c mice at the earlier time points. Our data suggest that resistance or susceptibility to intranasal pneumococci may have an association with recruitment and/or function of neutrophils.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 10:47:01